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1、儿科药学杂志2017年第23卷第8期JournalofPediatricPharmacy2017,Vol郾23,No郾8·11·doi:10郾13407/j.cnki.jpp郾1672鄄108X郾2017郾08郾004·论著·苯丙酮尿症患儿早期治疗依从性对智力发育的近期影响易燕,刘芳,柴艳婷,纪宏先,李珍(湖北省十堰市妇幼保健院,湖北十堰摇442000)[摘要]目的:探讨苯丙酮尿症(PKU)患儿早期治疗依从性对其预后的影响,并分析提升早期治疗依从性的措施。方法:选取2005年1月至2015年1月十堰市妇幼保健院新生儿筛查分中心筛查确诊的PKU患
2、儿74例为研究对象,回顾性分析其病历资料,按早期治疗依从性是否良好分为依从性良好组和依从性不佳组,比较两组患儿一般资料、家庭情况、身高、体质量及智力变化情况。结果:治疗依从性良好组共48例,治疗依从性不佳组共26例,两组患儿母亲学历、家庭年收入、确诊时间、是否参与医保比较差异均有统计学意义(P<0郾05);两组身高逸中位数、体质量逸中位数比例比较差异无统计学意义(P>0郾05),但治疗依从性良好组神经行为发育量表(Gesell发育量表)各行为能区评分均高于治疗依从性不佳组,差异有统计学意义(P<0郾05)。结论:PKU患儿早期治疗依从性较差,主
3、要受家庭情况影响,较差的早期治疗依从性可能对患儿智力发育造成不良影响,需注意预防。[关键词]苯丙酮尿症;依从性;新生儿;预后;智力发育[中图分类号]R725摇摇摇摇摇摇[文献标识码]A摇摇摇摇摇摇[文章编号]1672鄄108X(2017)08鄄0011鄄03ShortTermEffectofEarlyTreatmentComplianceonMentalDevelopmentinChildrenwithPhenylketonuriaYiYan,LiuFang,ChaiYanting,JiHongxian,LiZhen(ShiyanMaterna
4、landChildHealthCareHospitalofHubeiProvince,HubeiShiyan摇442000,China)[Abstract]Objective:Tostudytheeffectofearlytreatmentcomplianceontheprognosisofchildrenwithphenylketonuria(PKU),andtoanalyzethemeasurestoimprovethecomplianceofearlytreatment郾Methods:SeventyfourchildrenwithPKU
5、diagnosedbyShiyanMaternalandChildHealthCareHospitalNeonatalScreeningCenterfromJanuary2005toJanuary2015wereselectedasthesubjects,Themedicalrecordswereretrospectivelyanalyzed郾Accordingtoearlytreatmentcompliance,allchildrenweredividedintogoodcompliancegroupandpoorcompliancegrou
6、p,comparedthetwogroupswithgeneralinformation,familystatus,height,bodymassandmentalchanges郾Results:Therewere48casesingoodcompliancegroupand26casesinpoorcompliancegroup,thedifferencesinmother爷seducationbackgroud,familyannualincome,diagnosistimeandparticipationinmedicalinsuranc
7、ebetweenthetwogroupswerestatisticallysignificant(P<0郾05),thedifferenceshadnostatisticalsignificanceinweight逸medianandheight逸medianintwogroups(P>0郾05)郾ThescoresofGesellbehavioralscaleofbehaviorfunctionareasingoodcompliancegroupwerehigherthanthoseofthepoorcompliancegroup,thedi
8、fferenceswerestatisticallysignificant(P<0郾05)郾Conclusion:Theearlytreatmentc
