DNA修复基因ERCC1在胃癌组织中的表达及其意义

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1、上海交通大学硕士学位论文DNA修复基因ERCC1在胃癌组织中的表达及其意义姓名：龚玮华申请学位级别：硕士专业：消化内科指导教师：靖大道20080507上海交通大学医学院DNA修复基因ERCC1在胃癌组织中的表达及其意义N3期、NO+N1期与N2+N3期比较，ERCC1表达具有显著差异(P<0.05)。结论：ERCC1在胃癌组织中表达率为52.50%。胃癌组织中ERCC1表达与其临床病理分期密切相关，临床分期越高，ERCC1表达率越高；ERCC1表达与肿瘤浸润深度（T分期）和淋巴结转移（N分期）密切相关，肿瘤浸润深度越深，淋巴结

2、转移越多，其表达率也随之升高。提示ERCC1表达率有可能成为预测胃癌预后的生物学指标之一。关键词：胃癌，ERCC1，TNM分期上海交通大学医学院DNA修复基因ERCC1在胃癌组织中的表达及其意义THEEXPRESSIONOFERCC1INHUMANGASTRICCANCERABSTRACTBackground:ERCC1isanimportantmemberoftheDNArepairgenefamily.Itslowexpressionisoftenassociatedwithgeneticinstabilityleadin

3、gtomoremalignanttumors.Objectives:Toinvestigatetheexpressionofexcisionrepaircrosscomplementinggenes1(ERCC1)ingastriccancertissueandexploretherelationshipbetweenERCC1andtheclinicalstagesofgastriccancer.Methods:ExpressionlevelsofERCC1proteinsin40patientswithgastriccan

4、cerweredetectedwithimmunohistochemistry.Expression2differencesofERCC1ingastriccancertissueswereanalyzedwithXtest.Results:1.TheexpressionrateofERCC1ingastriccanceris52.50%.2.TheexpressionrateofERCC1invariouspathologyclassificationofgastriccancerissimilar(P>0.05).3.Th

5、eexpressionofERCC1issignificantlycorrelatedwithclinicalstageoftumor,stageoflymphoidnode(P<0.05).4.TheexpressionrateofERCC1instageIVissignificantlyhigherthanthatinstageI,II;andstageⅢ+ⅣhigherthanstageⅠ+Ⅱ.5.Carryingonthelaminationanalysisdemonstrationto上海交通大学医学院DNA修复基因

6、ERCC1在胃癌组织中的表达及其意义gastriccancer'sinfiltrationdepth,theexpressionrateofERCC1instageT3,T4issignificantlyhigherthantherateinstageT2(P<0.05).6.Carryingonthelaminationanalysisdemonstrationtolymphaticmetastasisofthegastriccancerpatients,theexpressionofERCC1instageN3issign

7、ificanthigherthantherateofinstageN0,andN0+N1higherthanN2+N3(P<0.05).Conclusion:TheexpressionrateofERCC1inhumangastriccanceris52.50%.TheexpressionsofERCC1weresignificantlyincreasedinadvancedstageofgastriccancerandcorrelatedwithclinicalstageoftumorandstageoflymphoidno

8、de.ItimpliesthatERCC1maybeoneofprognosticbiologicalparametersofgastriccancer.Keywords:gastriccancer,ERCC1,TNMstaging上海交通大学医学院DNA修复基因ERCC1在