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ID:36411962
大小:7.76 MB
页数:74页
时间:2019-05-10
《PH敏感性PMAA类水凝胶的合成及性能研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、西南交通大学硕士学位论文pH敏感性PMAA类水凝胶的合成及性能研究姓名:单连海申请学位级别:硕士专业:生物化学与分子生物学指导教师:张志斌20080408西南交通大学硕士研究生学位论文第1l页在释药时间上,基本上能够跟微球在结肠内的停留时间相吻合。关键词:“智能’’水凝胶;共混微球;体外释放实验西南交通大学硕士研究生学位论文第1II页Abstract“Intelligent"polymerhydrogelswerethosepolymerswhichcouldrespond、枥也largepropertychangestosmallphysicalorchemicalstim
2、ulationssuchastemperatureandpH,andcouldperformsensing,processingandactuatingfunctions.and“intelligent”polymerhydrogelshaveagoodapplicationstomedicmesandbiotechnologyandtheirpromisingpotentialityofdevelopment.ThepolyacrylicacidsizehydrogelsbelongstothepH·sensitivehydrogels,changingthepnofthe
3、environmentwouldcausethephasechangingofthepolyacrylicacidsizehydrogels.Thepapergivesasystemstudyonthepreparationandthepropertiesofthepolymethacrylicacidhydrogels(PMAA),First,wesynthesisthepolymethacrylicacidhydrogels,anddetermineditsstructurebyInfraredSpectrum.thenwepreparetheblendmicrosphe
4、resbyblendingthesodiumofpolymethacrylicacidwithsodiumalginate,andweobservetheinternalandexternalstructuresoftheblendmicrospheresbyscanningelectronmicroscope,andgiveastudyontheexternal·load-drugexperiment.Mainresultswereasfollows:1、Weusemethacrylicacidforinitialrawmaterialsbyfreeradicalreact
5、ionynthesisthePMAAhydrogelsat40*Candgivearesearchonhisproperties,Theresultshowedthat:PMAAhydrogelsshowedsignificantlypH—sensitive,andthepHincreased,theswellingde铲eeincreased;However,thecrosslinkingagentcontentincreased,theswellingdegreedecreased.2、Wegiveastudyonthepreparationofsodiumalginat
6、emicrosphereswiththesodiumalginateasmaterial,Theresultshowedthat:Whentheconcentrationofsodiumalginateismorethan2.5%andtheconcentrationofCaCl2ismorethan2.0%,theacquiredsodiumalginatemicrosphereshaveabetterroundresistance西南交通大学硕士研究生学位论文第1V页andstrength,andsodiumalginatemicrospheresshowsbeRersw
7、ellingpropertiesinpn6.8orpH7.4,itsessenceoftheswellingisthattheexchangeofNa+-Ca2+causedsol—gelvariation.3、Byblendingthepolymethacrylicacidsobiumandsodiumalginate,wepreparetheblendmicrospheresandmaketheswellingvariationbetweenpH6.8-7.4inordertomakethedrug
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