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1、普罗布考Phenol,4,4‘-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-.Acetonebis(3,5-di-tert-butyl-4-hydroxyphenyl)mercaptole[23288-49-5].4，4′-[(1-甲基亚乙基)二硫]双[2,6-二(1,1-二甲乙基)苯酚]。双（3，5-二叔丁基羟基苯硫）缩丙酮。Probucolcontainsnotlessthan98.0percentandnotmorethan10
2、2.0percentofC31H48O2S2,calculatedonthedriedbasis.按干燥品计算，普罗布考含C31H48O2S2应为98.0%~102.0%。Packagingandstorage-Preserveinwell-closed,light-resistantcontainers.包装与贮存：密封，遮光保存。USPREFERENCESTANDARDS<11>—美国药典标准品USPProbucolRS美国药典普罗布考对照品USPProbucolRelatedCompoundARS2,2',
3、6,6'-Tetra-tert-butyldiphenoquinone.C28H40O2408.63美国药典普罗布考有关化合物A对照品2,2’,6,6’-四叔丁基二苯醌USPProbucolRelatedCompoundBRS4,4'-(Dithio)bis(2,6-di-tert-butylphenol).C28H42O2474.78美国药典普罗布考有关化合物B对照品4,4’-(二硫)双（2,6-二叔丁基苯酚）USPProbucolRelatedCompoundCRS4-[(3,5-Di-tert-butyl-
4、2-hydroxyphenylthio)isopropylidenethtio]-2,6-di-tert-butylphenol.C31H4802S2516.86美国药典普罗布考有关化合物C对照品4-[(3,5-二叔丁基-2-羟苯硫)亚异丙基硫]-2,6-二叔丁基苯酚Identification,InfraredAbsorption<197K>.鉴别，红外吸收<197K>项下.MELTiNGRANGE,Class/<741>:between124°and127°,adriedspecimenbeingused.熔
5、点范围，按Class/<741>项下测定：干燥样品应为124°~127°。LOSSONDRYING<731>—Dryitinvacuumat80°for1hour:itlosesnotmorethanl.0%ofitsweight.干燥失重，按<731>项下测定，80°减压干燥1小时，减失重量不得过1.0%。RESIDUEONIGNITION<281>:0.1%.炽灼残渣，按<281>项下测定：0.1%HEAVYMETALS,Method//<231>:0.002%.重金属,按<231>项下第Ⅱ法：0.002%R
6、elatedcompounds—有关化合物.Mobilephase—Prepareamixtureofn-hexaneanddehydratedalcohol(4000:1).Makeadjustments,ifnecessary(seeSystermSuitabilityunderchromatography<621>)流动相—正己烷和无水乙醇按4000:1配制。如果有必要，可以适当调整（见色谱法<621>项下）。Referencesolution1—Dissolveanaccuratelyweighedqua
7、ntityofUSPProbucolRelatedCompoundARSinn-hexane,anddilutequantitativelyandstepwisewithn-hexanetoobtainasolutionhavingaknownconcentrationofabout10μgpermL.参比溶液1—将精密称定的USP普罗布考有关化合物A对照品溶解于正己烷中，并用正己烷稀释至浓度约为10μg/mL。Referencesolution2-Dissolveanaccuratelyweighedquant
8、ityofUSPProbucolRelatedCompoundBRSinn-hexane,anddilutequantitativelywithn-hexanetoobtainasolutionhavingaknownconcentrationofabout0.1mgpermL.参比溶液2—将精密称定的USP普罗布考有关化合物B对照品溶解于正己烷中，并用正己烷稀释至浓度约
