生物信息数据挖掘若干关键问题研究与应用

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1、後多大学博士学位论文生物信息数据挖掘若干关键问题研究与应用院系：专业：姓名：指导教师：完成日期：复旦大学博士学位论文ABSl∽T·Il·ABSTRACTDatamininghasbeenanactivefieldofstudyformorethanadecade，andanumberofalgorithmsaredevelopedtodealwitllallsortsofdatamiIlingproblems．Thesealgorithmsemployavarietyofmethodologies，includings

2、tatistics，artificialintelligence，machinelearning，anddigitalsignalprocessingandSOon．Inrecentyears，dataminingtechnologiesaresuccessfullyappliedtovariousindustriesandhavedemonstrateditsknowledgediscoverypower．Thefocusisnowontailoringthedataminingtechniquestospecifi

3、capplications．Aseriesofbreakthroughshasbeenmadeinlifesciencerecently．AsaresultofthesuccessfulexecutionoftheHumanGenomeProjectrHGP)andrelatedadvancementinmodembiology,ahugeamountofdatahasbeenaccumulated，providingastrongdatabaseforuncoveringthesecretoflife．Biologi

4、caldataisrichinvariety,andhigh—throughputwimhighdimensions．Inessence．ithasheterogeneityandnetworkcharactersthatarefarbeyondthepoweroftraditionalanalyticalmeans．Theanalysisofthesebio—databecomesthebottleneckofbiologicalresearch．Applyinginformationtechnologytomole

5、cularbiologygivesariseabrandnewfield，bioinformatics．Asalleffectivewayoffindingtheneedle(biologicalknowledge)fromahaystack(rawdata)，datamininghasalsobecomeincreasinglyimportantinbioinformaticsstudy．Asaresultoftheprogressofthegenomeresearchandtheadventofmanyhighth

6、roughputtechnologies，profoundchangesaretakingplaceintheresearchmethodologyofmodembiosciences．Eventraditionallyexperiment-basedsubjectsmoreandmoreutilizebioinformaticstoolstointerpretexperimentaldataandtogatherfruitfidhintsonexperimentaldesign．Therefore，findingef

7、fectiveanalysistoolsbecomeapressingissuefortheadvancementofmodembiologicalsciences．Computerscientistshavealotofinterestsingettinginvolvedinbioinformaticsdataanalysis．Asamajormethodology,datamininghasapromisingroletoplayinthisendeavor．However,researchesondatamini

8、nginbiologyarestillinapreliminaryphaseandarefacingalotofchallenges．Howtoapplyvariousdataminingtechniqueseffectivelytobiologicalinformationanalysisisahotsubjecttoday．T