分子印迹材料及量子点在分析化学中的应用

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1、兰州大学博士学位论文分子印迹材料及量子点在分析化学中的应用姓名：姜晓满申请学位级别：博士专业：化学分析化学指导教师：张海霞20090501姜晓满兰州人学博I：学位论文中文摘要和静态吸附试验显示，与传统块聚合方法制各的MIPs材料相比，乳液聚合不但实验方法简便，而且MINs材料具有更好的形貌和更高的吸附容量。4．使用水相合成法、以巯基乙酸为稳定剂制备了三种不同发光的水溶性CdTe量子点溶液，分别使用透射电镜(TEM)、荧光光谱(FL)和紫外光谱(UV)技术对该量子点进行了表征。选取其中一种量子点与胰岛素

2、分子的相互作用体系为研究对象，采用了荧光光谱技术对量子点和生物分子之间的相互作用进行了探讨。通过对胰岛素对CdTe的淬灭常数的计算，判断出胰岛素对CdTe的淬灭属于静态淬灭行为。另外，通过对不同盐浓度和酸度环境下淬灭效率的实验，得出以巯基乙酸为稳定剂的CdTe量子点和胰岛素之间的相互作用以静电作用为主。关键词：分子印迹；固相萃取；高效液相色谱；荧光量子点；纳米分子印迹材料AbstractWiththerapiddevelopmentofscienceandtechnology,analyticalsc

3、ienceisfacingthenewopportunityandrigorouschallenge．Sensitive，rapid，reproducible，simpleandaccurateanalyticalmethodsarerequiredforthedeterminationoftracecomponentsingeological，biologicalandenvironmentalsamples．Althoughmanyinstrumentanalysismethodspossessi

4、nghighersensitivityandselectivityhavebeendevelopedrecently,pre·concentrationandanalysisoftraceelementsisstillnecessarybeforethemoreaccuratemeasurementbyanalyticalinstrumentsinreality．Thepre-concentrationandanalysisoftracedementswilldependOildifferentads

5、orptionmaterialswithhigherselectivityandlargeradsorptioncapacityandappropriateseparationmethods．Inthisresearchpaper,severalnewadsorptionmaterialsalesynthesizedinordertopre-concentrationandseparationoftracecomponents．Theiradsorptionandselectivitycharacte

6、risticsfortracecomponentshavebeeninvestigatedsystematically．Themoredetailednoveltyofthisresearchcanbecategorizedasfollowing：1．Anovelandsimpleimprintedamino—funetionalizedsilicagelmaterialWassynthesizedbycombiningasurfacemolecularimprintingtechniquewitha

7、sol-gelprocessonthesupporterofactivatedsilicagelforsolid—phaseextraction—hi．ghperformanceliquidchromatography(SPE-HPLC)determinationofbisphenolA(BPA)．TheBPA-imprintedsilicasorbentandnon—imprintedsilicasorbentwerecharacterizedbyFT-IRandthestaticadsorptio

8、nexperiments．ThepreparedBPA—imprintedsilicasorbentshowedhighadsorptioncapacity,significantselectivityandgoodsiteaccessibilityforBPA．Furthermore,thedifferenceoftheretentioncharacteristicsofBPAontheC8SPEcolumnandBPA-imprintedsilica