髌骨脱位及早期复位对幼兔股骨滑车沟发育的影响

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1、授予单位代码—10089学号或申请号20122259H妗(E搿大杳HebeiMedicalUniversity硕士学位论文科学学位髌骨脱位及早期复位对幼兔股骨滑车沟发育的影响研究生：王胜杰导师：王飞教授专业：外科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的

2、专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签名:二级学院领导盖章：2^年3月夕日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：MJL导师签名:身目录中文摘要·················································································1英文摘要·

3、················································································3英文缩写·················································································7研究论文髌骨脱位及早期复位对幼兔股骨滑车沟发育的影响前言······································································8材料与方法····

4、·····························································8结果·············································································11附图···································································15附表···························································

5、··············19讨论········································································21结论···········································································23参考文献···································································24综述复发性髌骨脱位的研究及治疗进展··············

6、··················27致谢··················································································40个人简历···········································································41中文摘要髌骨脱位及早期复位对幼兔股骨滑车沟发育的影响摘要目的：髌骨脱位是临床上常见的疾病。通过临床研究学者们发现大部分髌骨脱位的患者存在股骨滑车发育不良的现象，因此大部分学者认

7、为股骨滑车发育不良是导致复发性髌骨脱位的重要因素之一。但是对于股骨滑车发育不良的原因目前研究尚浅。研究发现先天性髋关节脱位是引起髋臼发育不良的主要原因，考虑到膝关节和髋关节非常相似，我们通过动物实验证实早期髌骨脱位可以导致正常发育的幼兔滑车发育不良。临床上对髋臼发育不良的治疗过程中发现对脱位的髋关节早期复位可以改善髋臼的后天发育。本动物实验的目的是研究对脱位的髌骨早期复位是否能够改善幼兔股骨滑车沟的发育。方法：60只一个月龄大的新西兰白兔（由河北医科大学动物中心提供）体重290–320g，随机分成4组（N=15）即：空白对照组、早期复位实验组、

8、晚期复位实验组、脱位组。空白对照组不进行髌骨脱位手术，其他三组兔子进行髌骨脱位手术，麻醉后对兔子两后腿膝关节进行备皮，常规消毒，铺无菌单，沿膝关节正中