新型二茂铁类手性膦—亚磺酰胺配体的合成及其在不对称催化反应中的应用

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1、分类号R914UDC615密级公开新型二茂铁类手性膦-亚磺酰胺配体的合成及其在不对称催化反应中的应用马江微培养类别全日制学位类型专业学位一级学科(专业类)药学二级学科(专业)药物研发与评价研究方向不对称催化合成指导教师姜茹教授培养单位药学系药物化学教研室二O一五年五月第四军医大学硕士学位论文目录缩略语表·······························································································5中文摘要············································

2、···················································7英文摘要·······························································································9前言·································································································11文献回顾·······································

3、·······················································13正文······························································································35第一部分新型手性膦-亚磺酰胺二茂铁配体的设计合成·······························351.1配体的设计············································································

4、··351.2配体的合成··············································································351.2.1中间81的合成····································································361.2.2中间体82的合成·································································361.2.3中间体83的合成·····························

5、····································371.2.4手性膦-亚磺酰胺配体（L1-L7）的制备······································371.3结论·······················································································38第二部分新型手性配体在不对称烯丙基取代反应中的催化活性研究··············392.1不对称烯丙基取代反应·········································

6、·······················392.1.1手性配体的筛选····································································402.1.2溶剂筛选·············································································412.1.3碱、添加剂和反应温度对AAA反应的影响································422.1.4AAA反应的底物扩展····························

7、································432.2结论························································································46第三部分新型手性配体在金属铑催化的不对称芳基化反应中的催化活性研究·473.1铑催化的不对称芳基化反应············································