不同hbv-dna载量水平的乙肝肝硬化患者的血清肿瘤标志物检测分析

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1、授予单位代码１００８９１学号或申请号．１３１７８巧？作忘斜尖多ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ硕±学位论文在职科学学位不同ＨＢＶ－ＤＮＡ载量水平的乙肝肝硬化患者的血清肿瘤标志物检测分析学位申请人：杨华导师；金玉怀教授专业：病原生物学二级学院：基础医学院２０１５年１０月河北医科大学学位论文使用授权及知识产权巧属承错本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。

2、凡发表与学位论文主要内容相关的论文一，第署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识归河北医辭大学所有。否则，承担相应法律责任。‘４一、—由，？一一，辛：賢占研究生签名导师签讀每幸＜兵级学院讀导盖章巧春和！［％－．年月日河北医科大学研究生学位论义独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名导章／＾，ｆ矣：＾令两＼竿月／曰＇．＇目

3、录中文摘要··············································································1英文摘要··············································································4英文缩写··············································································7研究论文不同HBV-DNA载量水平的乙肝肝硬化患者的血清肿瘤标志物检测分析前言·

4、·············································································8材料与方法·····································································9结果··············································································12附表·····················································

5、·························14讨论··············································································17结论··············································································21参考文献········································································21综述肝癌肿瘤标志物AFP-L3、GP73、

6、CEA及AFP的研究进展······25致谢····················································································39个人简历··············································································40中文摘要不同HBV-DNA载量水平的乙肝肝硬化患者的血清肿瘤标志物检测分析摘要目的：我国为乙肝肝硬化高发国家，肝炎后肝硬化可进一步发展为原发性肝细胞肝癌。有研究表明，肝癌相关的肿瘤标志物在多种肝脏

7、疾病患者血清中可有不同程度含量增高。本研究通过乙肝肝硬化患者血清中肝癌相关的肿瘤标志物含量及HBV-DNA载量检测分析，以期发现HBV-DNA载量和乙肝肝硬化患者的病程进展的关系及肝癌发生的风险，为及时进行有效的抗病毒干预,减少或推迟肝癌的发生提供理论依据。方法：1一般资料1.1乙肝肝硬化组选择邢台市第三医等三家医院2011年1月至2013年12月期间临床已明确诊断的乙肝肝硬化住院患者30例，年龄18-65岁，所有患者均符合乙肝肝硬化的诊断标准，排除：①其他原因引起的肝硬化患者；②合并胆管癌、胃癌等其它肿瘤；③妊娠