sirt1抑制pdgf-bb诱导的血管平滑肌细胞葡萄糖摄取和代谢

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1、授予单位代码10(丨89-学号或申请号20122598H妗(E科大爻HebeiMedicalUniversity硕士学位论文科学学位SIRT1抑制PDGF-BB诱导的血管平滑肌细胞葡萄糖摄取和代谢研究生：陈鹏导师：韩梅教授专业：生物化学与分子生物学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论

2、文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签章：二级学院领导盖章年）月曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：兮,fh年$月v日目录中文摘要··············································

3、······························································1英文摘要············································································································3英文缩写····················································································

4、························5研究论文SIRT1抑制PDGF-BB诱导的血管平滑肌细胞葡萄糖摄取和代谢前言············································································································6材料与方法·······················································································

5、·········7结果··········································································································11附图··········································································································14讨论································

6、··········································································18结论··········································································································19参考文献··········································································

7、························19综述SIRT1功能的研究进展······································································22致谢··················································································································40个人简历······························

8、············································································41中文摘要SIRT1抑制PDGF-BB诱导的血管平滑肌细胞葡萄糖摄取和代谢摘要目的：血管平滑肌细胞（VSMCs）中葡萄糖摄取和代谢的异常增加能导致动脉