ndrg2在人结直肠癌谷氨酰胺分解代谢中的作用与分子机制研究

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1、分类号UDC密级公开NDRG2在人结直肠癌谷氨酰胺分解代谢中的作用与分子机制研究徐欣元培养类别全日制学位类型学术学位一级学科(专业类)生物学二级学科(专业)生物化学与分子生物学研究方向肿瘤代谢指导教师药立波培养单位基础部二O一五年五月第四军医大学硕士学位论文目录缩略语表·······································1中文摘要·······································5英文摘要·······································8前言······················

2、················12文献回顾······································131.肿瘤代谢重编程的特征·····························131.1肿瘤糖代谢重编程特征····························141.2肿瘤脂代谢重编程的特征···························161.3肿瘤氨基酸代谢重编程的特征·························182.癌基因、抑癌基因与肿瘤代谢重编程的发生····················212.1代谢重编程的发

3、生与基因的变化························212.2癌基因活化与代谢重编程的发生························222.3抑癌基因失活与代谢重编程的发生·······················232.4癌基因与抑癌基因的协同作用与代谢重编程的发生················253.抑癌基因NDRG2在肿瘤发生和发展中的作用····················263.1NDRG家族··································263.2NDRG2···························

4、········27正文······································31第一部分NDRG2介导的代谢组学变化························311材料····································312方法····································323结果····································344讨论····································38第二部分NDRG2抑制谷氨酰胺分解代谢········

5、···············391.材料····································392方法····································413.结果····································454.讨论····································48第三部分NDRG2抑制谷氨酰胺分解代谢的分子机制··················491.材料····································492.方法·············

6、·······················503.结果····································534.讨论····································57第四部分NDRG2抑制谷氨酰胺分解代谢的临床意义··················581.材料····································58第四军医大学硕士学位论文2.方法····································593.结果··································

7、··624.讨论····································65小结······································66参考文献······································67个人简历和研究成果································76致谢······································77第四军医大学硕士学位论文缩略语表缩略词英文全称中文全称ACCAcetyl-CoAcarboxylase乙酰辅酶A羧化酶AD