cyr61介导ddr2过分泌mmp1的分子机制及其在ra滑膜细胞侵袭中的作用研究

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1、分类号Q7UDC616-092密级公开CYR61介导DDR2过分泌MMP1的分子机制及其在RA滑膜细胞侵袭中的作用研究黄同列培养类别全日制学位类型学术学位一级学科(专业类)生物学二级学科(专业)生物化学与分子生物学研究方向类风湿性关节炎发病机理指导教师张英起教授培养单位药学系生物制药学教研室二O一五年五月第四军医大学博士学位论文目录缩略语表·······························································································1中文摘要··················

2、·············································································3ABSTRACT····························································································7前言······························································································11文献回顾········

3、······················································································13正文······························································································29第一部分CYR61在RA滑膜组织中的表达状态分析···································291实验材料·····································

4、·················································302实验方法······················································································343实验结果······················································································404讨论·················································

5、···········································44第二部分DDR2活化对CYR61的表达调控及其分子机制研究·······················471实验材料······················································································472实验方法······················································································503实验结

6、果······················································································684讨论····························································································76第三部分CYR61对MMP1的表达调控及其对RA滑膜细胞侵袭功能的影响····791实验材料·························································

7、·····························792实验方法······················································································823实验结果····················································································1114讨论···············································