adam10、egfr、e-cadherin在乳腺癌中的表达及临床意义

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1、授予单位代码10089学号或申请号13857HebeiMedicalUniversity硕士学位论文在职科学学位ADAM10�EGFR�E_cadherin在乳腺癌中的表达及临床意义学位申请人：刘彦平导师：张静教授专业：外科学二级学院：河北省人民医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医

2、科大学所有。否则，承担相应法律责任。研究生签名公：^

3、^斜3级藏会讀盖章：、•/7目录中文摘要··············································································1英文摘要··························

4、····················································4英文缩写··············································································7研究论文ADAM10、EGFR、E-cadherin在乳腺癌中的表达及临床意义前言··············································································8材料与方法···································

5、··································9结果·············································································17附图·············································································19附表·············································································23讨论················

6、·····························································29结论·············································································33参考文献·······································································33综述ADAM10、EGFR与肿瘤关系的研究进展···························36致谢·····················

7、······························································48个人简历·············································································49中文摘要ADAM10、EGFR和E-cadherin在乳腺癌中的表达及临床意义摘要目的：受多重因素影响，女性乳腺癌发病率日趋增高，在部分国家和地区已成为女性首位杀手，随着医学技术的不断发展，患者的无病生存期逐步延长，但局部侵袭及远处转移依然是乳腺癌患者所面临的最大威胁。肿瘤的侵袭和转移是一个复杂的

8、动态过程，包括细胞粘附性的改变，信号传导途径的激活，免疫逃避等多个环节。研究发现去整合素-金属蛋白酶家族（ADAMS）、表皮生长因子受体（EGFREpidermalGrowthFactorReceptor）、上皮钙粘蛋白（E-cadherin）与恶性肿瘤发生发展密切相关，本文通过检测ADAM10、EGFR和E-cadherin在乳腺癌组织、正常乳腺组织中的表达，探讨其与乳腺癌临床及病理特征（患者年龄、肿瘤长径、临床分期、组织学分级、淋巴结转移情