铝致大鼠海马神经元凋亡与突触可塑性损伤的关系及凋亡过程中caspase途径研究

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1、分类号：R135单位代码：10114密级：学号：2012100316铝致大鼠海马神经元凋亡与突触可塑性损伤的关系及凋亡过程中caspase途径研究Therelationbetweenneuronalapoptosisinducedbyaluminumandsynapticplasticityinjury,caspasespathwayofapoptosisprocessinrats研究生：聂小寒指导教师：牛侨教授专业名称：劳动卫生与环境卫生学研究方向：化学物的神经毒性学位类型：学术学位所在学院：公共卫生学院中国山西二〇一五年五月二十日目录中文摘

2、要................................................................................................................................I英文摘要..............................................................................................................................V常用缩写词中英文对照表...

3、..............................................................................................IX前言...................................................................................................................................11材料和方法.......................................

4、..............................................................................61.1实验材料................................................................................................................61.2实验方法.....................................................................

5、...........................................82结果...........................................................................................................................162.1大鼠基本情况..............................................................................................

6、........162.2神经行为测试结果..............................................................................................162.3电生理实验检测结果..........................................................................................262.4流式细胞术测细胞凋亡实验结果.....................................

7、.................................292.5实时荧光定量PCR结果.....................................................................................312.6Elisa检测蛋白结果..............................................................................................362.7神经元凋亡与突触可塑性损伤相关性分析........

8、..............................................403讨论........................