糖尿病大鼠肾组织nrf2、nqo1的表达及虾青素对其干预作用的研究

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1、授予单位代码10089学号或申请号20丨22213K於(E搿大5HebeiMedicalUniversity硕士学位论文科学学位’糖尿病大鼠肾组织Nrf2�NQ01的表达及虾青素对其干预作用的研究研究生：张健美导师：李英教授专业：内科学—级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要

2、内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。二级学院领导盖章：i“夂年？月^曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行r审定。本论文由本人独立撰写，文责自负。w年月0日目录中文摘要···············································

3、······························1英文摘要·············································································4英文缩写·············································································7研究论文糖尿病大鼠肾组织Nrf2、NQO1的表达及虾青素对其干预作用的研究前言·················

4、····························································8材料与方法····································································8结果·············································································20附图·································

5、············································22附表·············································································36讨论·············································································40结论·········································

6、····································42参考文献·······································································43综述糖尿病肾病早期肾损伤检测指标的研究进展·······················46致谢···················································································53个人简

7、历·············································································54中文摘要糖尿病大鼠肾组织Nrf2、NQO1的表达及虾青素对其干预作用的研究摘要目的：糖尿病肾病（DiabeticNephropathy,DN）是糖尿病（Diabetesmellitus,DM）患者的主要慢性并发症之一，也是导致终末期肾衰竭的重要病因。其主要临床特点为逐渐出现的蛋白尿及肾功能损害，病理表现为肾小球基底膜增厚、系膜扩张、间质纤维

8、化等。在糖尿病肾脏损伤的发生发展过程中，氧化应激、炎症反应以及肾脏固有细胞的凋亡发挥了重要作用。高糖环境可以导致机体产生过多的活性氧（Reactiveoxygenspecies,ROS），从而进一步活化相关信号传导通路，致使细胞因子及生长因子的失调。核因子E2相关因子（NuclearfactorE2–relatedfactor2,Nrf2）是机体调节抗氧化反应的重要转录因子。Nrf2能够激活抗氧化反应元件（Anti-oxidativeresponseelement,ARE）的基因序