沧州人群红细胞分布宽度与冠脉病变严重程度的关系

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1、授予单位代码10089^学号或申请号12239^JCW.HebeiMedicalUniversity硕士学位论文在职科学学位沧州人群红细胞分布宽度与冠脉病变严重程度的关系学位申请人：韩海莉导师：张军教授专业：内科学二级学院：沧州市中心医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学

2、，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。j一月“曰目录中文摘要·············································································1英文摘要······························

3、···············································3研究论文沧州人群红细胞分布宽度与冠脉病变严重程度的关系前言·············································································5对象与方法····································································5结果·································

4、············································8附图·············································································10附表·············································································13讨论·······················································

5、······················17结论·············································································21参考文献·······································································21综述红细胞分布宽度临床应用进展···········································24致谢····················

6、·······························································40个人简历·············································································41中文摘要沧州人群红细胞分布宽度与冠脉病变严重程度的关系摘要目的：探讨沧州地区人群红细胞分布宽度(RDW)与冠状动脉病变严重程度的关系方法：收集2014年1月至2015年1月在沧州市中心医院和沧州市人民医院因胸痛疑诊冠心病或已明确冠心

7、病而行冠脉造影（CAG）检查的住院患者1014例。详细记录患者病史资料（年龄、性别、是否吸烟、是否合并高血压、糖尿病)，实验室结果（RDW）及冠脉造影结果。根据冠状动脉造影结果详细记录受累血管支数、每支血管狭窄的部位及程度，采用Gensini评分对各患者冠脉病变程度进行定量分析，采用四分法将评分结果分为四组：Ⅰ组(0-25)、Ⅱ组(26-50)、Ⅲ组(51-90)和Ⅳ组(>90)，分别比较各组间RDW水平，探讨本地区人群RDW水平与冠状动脉病变严重程度的关系；根据冠状动脉病变血管支数及其部位分为阴性组（血管完全光滑或仅有斑

8、块者）、单支病变组、双支病变组、三支病变组、左主干病变组，分别比较各组间RDW水平，从不同角度进一步探讨本地区人群RDW与冠状动脉病变严重程度的关系；用SPSS19.0统计软件分析结果。结果：1随Gensini积分的增加RDW值逐渐升高，Ⅱ组RDW数值高于Ⅰ组，Ⅲ组RDW数值高于Ⅰ组，Ⅳ组RDW数值明显