复荣通脉胶囊对糖尿病大鼠胸主动脉enos、adma及nf-κb表达影响的实验研究

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1、授予单位代码10089学号或申请号20122446H泠(E科大交HebeiMedicalUniversity硕士学位论文科学学位复荣通脉胶囊对糖尿病大鼠胸主动脉eNOS�ADMA及NF-KB表达影响的实验研究研究生：边云导师：田风胜教授专业：中西医结合临床二级学院：沧州中西医结合医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文，第一署名单位为

2、河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。研究生签名:Hx导师签章：二级学院领导•年）月I日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导老师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：‘导师签章：减年3月丨曰目录中文摘要·································································

3、············1英文摘要·············································································4英文缩写·············································································8研究论文复荣通脉胶囊对糖尿病大鼠胸主动脉eNOS、ADMA及NF-κB表达影响的实验研究前言·····················································

4、························9材料与方法····································································10结果·············································································14附图·············································································16附表············

5、·································································26讨论·············································································28结论·············································································32参考文献···········································

6、····························32综述复荣通脉胶囊对糖尿病大血管病变的研究探讨····················36致谢···················································································43个人简历·············································································44中文摘要复荣通脉胶囊对糖尿病大鼠胸主动脉eNOS、ADMA及NF

7、-κB表达影响的实验研究摘要目的：通过观察益气养阴、活血通络的中药复方制剂—复荣通脉胶囊对糖尿病大鼠eNOS、ADMA、NF-κB表达的影响，进一步阐述其防治糖尿病血管病变的作用机制，为临床应用提供理论依据。方法：60只成年雄性Wistar大鼠随机分为两组，正常对照组10只，造模组50只。造模组大鼠禁食12h后，一次性腹腔注射STZ60mg/kg（STZ临用前用0.1M柠檬酸钠缓冲液配成浓度为1％、pH＝4.2的溶液），正常组腹腔注射等量的柠檬酸钠缓冲液。72h后尾静脉取血，测血糖≥16.7mmol／L，确定为糖尿病大鼠。成模后，随机抽取40只分

8、为糖尿病组（10只）及复荣通脉胶囊低剂量组（10只）、复荣通脉胶囊中剂量组（10只）、复荣通脉胶囊高剂量组（10只）。复荣通脉胶囊中剂量