白细胞介素17（1l-17）在咬合创伤及牙周炎大鼠实验模型牙周组织中的表达变化及意义

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1、授予单位代码10089学号或申请号20123117HebeiMedicalUniversity专业学位白细胞介素17(IL-17)在咬合创伤及牙周炎大鼠实验模型牙周组织中的表达变化及意义研究生：林瑶导师：张志勇教授专业：口腔医学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有

2、。否则，承担相应_律责任。研究生签名导师签章:二级学院领导盖章：，.-^年）月)。曰;,/河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：it治导师签章：“V曰77o目录中文摘要············································································1英文摘要····································

3、········································5英文缩写···········································································10研究论文白细胞介素17(IL-17)在咬合创伤及牙周炎大鼠实验模型牙周组织中的表达变化及意义前言···········································································11材料与方法···············································

4、···················11结果···········································································14附图···········································································18附表···········································································25讨论·······································

5、····································26结论···········································································32参考文献·····································································33综述白细胞介素17（IL-17）与牙周炎关系的研究进展·············36致谢·······························································

6、··················44个人简历···········································································45中文摘要白细胞介素17(IL-17)在咬合创伤及牙周炎大鼠实验模型牙周组织中的表达变化及意义摘要目的：分析咬合创伤伴牙周炎实验模型牙周组织中白细胞介素17(IL-17)在不同时间的表达变化以及其他病理组织改变情况，进一步明确咬合创伤与牙周炎以及IL-17与牙周炎的关系，为临床工作中疾病的治疗提供更理性的方法和实验依据。方法：选用购于河北医科大学实验动物中心的三个月大的Wistar雄性大鼠120

7、只，体重250-280g。清洁，良好的口腔卫生，没有口腔疾病，良好的咬合关系。随机将大鼠分为对照组（CG），咬合创伤组（OG），牙周炎组（PG），咬合创伤伴牙周炎组（OPG）四个组，30只大鼠为一组。再按照1d、3d、1w、2w、4w、6w将各组分成六小组，每组5只。对大鼠进行麻醉和消毒。麻醉是用100g/L浓度水合氯醛（3ml/Kg）腹腔注射，消毒是用1%碘酊和75%酒精消毒口腔的两侧黏膜。咬合创伤组(OG