毛细支气管炎患儿血清tnf-α、vegf的检测及临床意义

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1、授予单位代码10089学号或申请号13010HebeiMedicalUniversity硕士学位论文在职科学学位毛细支气管炎患儿血清TNF-a�VEGF的检测及临床意义学位申请人：赵会娟导师：张少丹主任医师专业：儿科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单

2、位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签^导师签章：二级学院领导盖章：�1年《月3曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名导师签章：彡1>/义年<月)曰目录中文摘要··········································

3、····································1英文摘要··············································································4英文缩写··············································································8研究论文毛细支气管炎患儿血清TNF-α、VEGF的检测及临床意义前言···················

4、···························································9材料与方法···································································10结果·············································································13附图·······································

5、······································15附表·············································································16讨论·············································································18结论····················································

6、·························23参考文献·······································································23综述毛细支气管炎的临床研究进展·········································27致谢···················································································34个人简历···

7、··········································································35中 文 摘 要 毛细支气管炎患儿血清TNF-α、VEGF的检测及临床意义摘要目的：毛细支气管炎是婴幼儿常见的一种下呼吸道感染性疾病，多见于1-6个月的小婴儿。毛细支气管炎主要由呼吸道合胞病毒引起。此病常发生在冬春季节，临床表现与一般感染性炎症不同，病情多在咳嗽发生后的2-3天逐渐加重，呼吸急促，伴有鼻翼扇动，胸凹陷等症状，严重者可出现紫绀、喘憋合并心力衰竭，

8、从而危及患儿生命。因此，对毛细支气管炎合并心力衰竭患儿给予早期治疗显得尤为重要。TNF-α（肿瘤坏死因子）及VEGF（血管内皮生长因子）作为炎症介质参与毛细支气管炎的发病过程。肿瘤坏死因子是单核巨噬细胞系统产生的具有肿瘤杀伤作用的细胞因子，并且对机体炎症和免疫应答有调节作用。TNF-α是由呼吸道上皮细胞、血管内皮细胞、外周血的中性粒细胞、嗜酸性粒细胞、T和B淋巴细胞、及NK细胞产生、释放。TNF-α的作用与在机体