基于脾脏免疫物质探讨卫气节律性变化的实验研究

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1、授予单位代码10089学号或中请号20122693HebeiMedicalUniversity禾斗#射立基于脾脏免疫物质探讨卫气节律性变化的实验研究研究生：吴园园导师：王亚利教授专业：中医基础理论二级学院：中医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河

2、北医科大学所有。否则，承担相应法律责任。研究生签名丨A导师签章月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名括导师签章:7•r年1月和曰目录中文摘要················································································1英文摘要·····················

3、···························································4英文缩写················································································6研究论文基于脾脏免疫物质探讨卫气节律性变化的实验研究前言················································································7材料与方法·················

4、······················································8结果··············································································10附图··············································································12附表·······················································

5、·······················16讨论··············································································18结论··············································································26参考文献········································································27综述中医学脾脏与卫

6、气的关系及脾脏相关免疫功能和细胞因子的研究进展····································································29致谢····················································································38个人简历··············································································39中文摘要卫气的物质基础

7、节律性变化和脾脏的免疫物质的关系实验研究摘要天人相应思想是贯穿于整个《黄帝内经》的核心思想，人禀天地之气而生，来自于天地之间，最终将归于天地之间，其生、老、病、死无一不是受到天地阴阳季节变化的影响。天人相应思想是指导中医学预防、诊断、治疗疾病过程中的基础理论。天地阴阳四时季节变化影响人体五脏六腑阴阳变化，从而产生对人体生理、病理功能产生影响，尤其是对人体五脏的影响更是密切。本课题从“脾为之卫”“脾坚则脏安难伤”和卫气具有防御功能的角度出发，研究天地阴阳四时季节更替变化对大鼠脾脏相关免疫细胞因子的影响，探讨与脾脏相关的免疫细胞因子随天地阴阳四时季节

8、更替的相应变化规律以及与卫气物质基础节律性变化的关系。为中医学天人相应理论的现代化研究及卫气物质基础研究，以及临床预防和治疗疾病提供理论