sirt3通过抑制p53改善线粒体自噬对衰老心肌发挥保护作用的机制研究

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1、分类号R541.4UDC616.1密级公开SIRT3通过抑制P53改善线粒体自噬对衰老心肌发挥保护作用的机制研究马颖培养类别非全日制学位类型学术学位一级学科(专业类)临床医学二级学科(专业)内科学（心血管病）研究方向心肌缺血性损伤及其机制研究指导教师李妍副教授（副主任医师）培养单位西京医院心血管内科二O一五年十一月第四军医大学硕士学位论文目录缩略语表··························································································

2、··································1中文摘要····························································································································4英文摘要··································································································

3、··························7前言··························································································································10文献回顾·············································································································

4、·············12正文··························································································································24第一部分SIRT3对衰老所致的心肌损伤发挥保护作用····································241材料···························································

5、···················································242方法··············································································································273结果·······························································································

6、···············324讨论··············································································································37第二部分SIRT3通过调节P53/Parkin改善线粒体自噬对衰老心肌损伤发挥保护作用···························································································

7、·······401材料··············································································································402方法··············································································································433结果························

8、······················································································484讨论···············································