shh和foxm1在上皮性卵巢肿瘤组织中的表达及临床意义

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1、授予单位代码10089学号或申请号13003对妗(E钭大空HebeiMedicalUniversity学位论文在职科学学位Shh和Foxml在上皮性卵巢肿瘤组织中的表达及临床意义学位申请人：王倒红导师：冯玉珍教授专业：妇产科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有n河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有

2、。否则,承担相应法律责任。研究生签名：师签章：二级学院领导盖章：年月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。，研究生签名：导师签章：,^0ur年艾月乂日目录中文摘要·············································································1英文摘要··········································

3、···································4英文缩写·············································································7研究论文Shh和Foxm1在上皮性卵巢肿瘤组织中的表达及临床意义前言·············································································8材料与方法·······························································

4、·····9结果·············································································13附图·············································································16附表·············································································19讨论···············································

5、······························21结论·············································································29参考文献·······································································30综述Sonichedgehog信号通路在卵巢癌中的研究进展··················34致谢·························································

6、··························44个人简历·············································································45中文摘要Shh和Foxm1在上皮性卵巢肿瘤组织中的表达及临床意义摘要目的:研究Shh和Foxm1在上皮性卵巢肿瘤组织中的表达及其临床意义。方法:采用免疫组织化学染色方法（IHC）检测74例卵巢组织标本（正常卵巢组织18例、卵巢良性肿瘤18例、上皮性卵巢细胞癌38例）中Shh蛋白和Foxm1蛋白的表达规律，并分析两种因子与上皮性卵巢细胞癌的临床分期、病理分级、病理类型及淋巴

7、结转移之间的关系，探讨其临床意义。结果:1Shh蛋白在正常卵巢组织中表达为阴性，而在卵巢良性肿瘤组织和上皮性卵巢细胞癌组织中呈阳性表达，阳性表达率分别为22.22%(4/18)和81.6%(31/38)，且在上皮性卵巢细胞癌中的阳性表达率明显高于卵巢良性肿瘤，P<0.05，差异有统计学意义。Foxm1蛋白在正常卵巢组织中表达为弱阳性，而在卵巢良性肿瘤和上皮性卵巢细胞癌组织中呈阳性表达，阳性表达率依次为11.11%(2/1