mir-99a与mir-146c在鸡毒支原体感染中的作用研究

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1、＾幸中｜｜义璋ＨＵＡＺＨＯＮＧＡＧＲＩＣＵＬＴＵＲＡＬＵＮＩＶＥＲＳＩＴＹ硕±学位论文Ｍ乂ＳＴＥＲＳＤＥＧＲＥＥＤＩＳＳＥＲＴＡＴＩＯＮｍ－－ｉＲ９９ａ与ｍｉＲ１４６ｃ在鸡毒支原体感染中的作用研究－ＳＴＵＤＹＯＮＩＮＦＥＣＴＩＯＮＭＥＣＨＡＮＩＳＭＯＦＭＩＲ９９ＡＡＮＤ－ＩＭＩＲ１４６ＣＡＧＡＩＮＳＴＭＹＣＯＰＬＡＳＭＡＧＡＬＬＩＳＥＰＴＩＣＵＭ王在巧研究化：ＣＡＮＤＩＤＡＴＥ：ＷＡＮＧＺＡＩＷＥＩ丽副教授诗师：彭秀ＳＵＰＥＲ

2、ＶＩＳＯＲ：ＡＳＳＯＣＩＡＴＥＰＲＯＦＥＳＳＯＲＰＥＮＧＸＩＵＬＩ专业：动物遗传育种与繁殖ＭＡＪＯＲ：ＡＮＩＭＡＬＧＥＮＥＴＩＣＳ，ＢＲＥＥＤＩＮＧＡＮＤ民ＰＲＯＤＵＣＴＩＯＮＥ研究方时：家食迸传育种ｆｉｅｌｄ：ｐｏｕｌｔｒｙｇｅｎｅｔｉｃｓａｎｄＢＲＥＥＤＩＮＧ中国武汉ＷＵＨＡＮ，ＣＨＩＮＡ二〇—五年六月？ＪＵＮＥ，２０１５ߚ㉏োᆚ㑻ढЁϮ໻ᄺ⸩຿ᄺԡ䆎᭛miR-99aϢmiR-146c೼叵↦ᬃॳԧᛳᶧЁⱘ԰⫼ⷨおStudyo

3、ninfectionmechanismofmiR-99aandmiR-146cagainstMycoplasmagallisepticum⸩຿ⷨお⫳:⥟೼⦂ᄺো:2012302110042ᣛᇐᬭᏜ:ᕁ⾔Бࡃᬭᥜᣛᇐᇣ㒘:啮♢䭓ᬭᥜᕁ⾔Бࡃᬭᥜ׌㡇㧡ࡃᬭᥜᴢϪࡃᬭᥜϧϮ˖ࡼ⠽䘫Ӵ㚆⾡Ϣ㐕Ⅺⷨおᮍ৥˖ᆊ⾑䘫Ӵ㚆⾡㦋ᕫᄺԡৡ⿄˖ᄺ⸩຿㦋ᕫᄺԡᯊ䯈˖2015.06ढЁϮ໻ᄺࡼ⠽⾥ᡔᄺ䰶Ϣࡼ⠽एᄺ䰶ѠƻϔѨᑈ᳜݁೑ᆊ㞾✊⾥ᄺ෎䞥˄31070154੠31270216˅䌘ࡽ乍ⳂSupportedbytheNatio

4、nalNaturalScienceFoundationofChina(31070154and31270216)miR-99aϢmiR-146c೼叵↦ᬃॳԧᛳᶧЁⱘ԰⫼ⷨおⳂᔩᨬ㽕..................................................................................................................................iABSTRACT.........................

5、..............................................................................................iii㓽⬹䆡㸼(ABBREVIATIONS).........................................................................................vi1ࠡ㿔...........................................

6、......................................................................................11.1叵↦ᬃॳԧⱘॅᆇ..............................................................................................11.2叵↦ᬃॳԧ㟈⮙ᴎ⧚................................................

7、..........................................11.3miRNA೼♢⮛Ёⱘⷨお䖯ሩ..............................................................................31.4miR-99೼⮒⮙Ёⱘⷨお䖯ሩ..............................................................................41.5miR-146೼⮒⮙Ёⱘⷨお

8、䖯ሩ............................................................................51.6ⷨおⳂⱘ੠ᛣН..................................................................................................52ᅲ偠ᴤ᭭੠ᮍ⊩.................................