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1、AgingoftheGenomeCover:atomicforcemicroscopy(AFM)imagesoftheOrc4subunitoforiginrecognitioncomplex(blue-yellowsphere)boundtotheDNAreplicationorigin(greenstrand),fromfissionyeast,Schizosaccharomycespombe.Theimageswereacquiredusingtapping-modeAFMinair(Gaczynskaetal.,Proc
2、.Natl.Acad.Sci.USA2004,101,17952–17957).Theillustrationiscomposedfromtwozoomed-inimages:intheleftimage1cmcorrespondstoapproximately1nm,andintherightimage1cmis5nm.Theheightscaleisrepresentedbyafalsecolorpalette,fromblue(about10nm)throughyellowandgreentoblack(backgrou
3、nd,0nm).AgingoftheGenomeThedualroleofDNAinlifeanddeathJanVijgBuckInstituteforAgeResearch,Novato,CA,USA33GreatClarendonStreet,OxfordOX26DPOxfordUniversityPressisadepartmentoftheUniversityofOxford.ItfurtherstheUniversity’sobjectiveofexcellenceinresearch,scholarship,an
4、deducationbypublishingworldwideinOxfordNewYorkAucklandCapeTownDaresSalaamHongKongKarachiKualaLumpurMadridMelbourneMexicoCityNairobiNewDelhiShanghaiTaipeiTorontoWithofficesinArgentinaAustriaBrazilChileCzechRepublicFranceGreeceGuatemalaHungaryItalyJapanPolandPortugalSi
5、ngaporeSouthKoreaSwitzerlandThailandTurkeyUkraineVietnamOxfordisaregisteredtrademarkofOxfordUniversityPressintheUKandincertainothercountriesPublishedintheUnitedStatesbyOxfordUniversityPressInc.,NewYork©JanVijg,2007ThemoralrightsoftheauthorhavebeenassertedDatabaserig
6、htOxfordUniversityPress(maker)Firstpublished2007Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,withoutthepriorpermissioninwritingofOxfordUniversityPress,orasexpresslypermittedbylaw,orundertermsag
7、reedwiththeappropriatereprographicsrightsorganization.EnquiriesconcerningreproductionoutsidethescopeoftheaboveshouldbesenttotheRightsDepartment,OxfordUniversityPress,attheaddressaboveYoumustnotcirculatethisbookinanyotherbindingorcoverandyoumustimposethesamecondition
8、onanyacquirerBritishLibraryCataloguinginPublicationDataDataavailableLibraryofCongressCataloginginPublicationDataDataavailableTypesetbyNewg
