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1、AgingoftheGenomeCover:atomicforcemicroscopy(AFM)imagesoftheOrc4subunitoforiginrecognitioncomplex(blue-yellowsphere)boundtotheDNAreplicationorigin(greenstrand),fromfissionyeast,Schizosaccharomycespombe.Theimageswereacquiredusingtapping-modeAFMinair(Gaczynskaetal.,Proc.Na
2、tl.Acad.Sci.USA2004,101,17952–17957).Theillustrationiscomposedfromtwozoomed-inimages:intheleftimage1cmcorrespondstoapproximately1nm,andintherightimage1cmis5nm.Theheightscaleisrepresentedbyafalsecolorpalette,fromblue(about10nm)throughyellowandgreentoblack(background,0nm
3、).AgingoftheGenomeThedualroleofDNAinlifeanddeathJanVijgBuckInstituteforAgeResearch,Novato,CA,USA33GreatClarendonStreet,OxfordOX26DPOxfordUniversityPressisadepartmentoftheUniversityofOxford.ItfurtherstheUniversity’sobjectiveofexcellenceinresearch,scholarship,andeducatio
4、nbypublishingworldwideinOxfordNewYorkAucklandCapeTownDaresSalaamHongKongKarachiKualaLumpurMadridMelbourneMexicoCityNairobiNewDelhiShanghaiTaipeiTorontoWithofficesinArgentinaAustriaBrazilChileCzechRepublicFranceGreeceGuatemalaHungaryItalyJapanPolandPortugalSingaporeSouth
5、KoreaSwitzerlandThailandTurkeyUkraineVietnamOxfordisaregisteredtrademarkofOxfordUniversityPressintheUKandincertainothercountriesPublishedintheUnitedStatesbyOxfordUniversityPressInc.,NewYork©JanVijg,2007ThemoralrightsoftheauthorhavebeenassertedDatabaserightOxfordUnivers
6、ityPress(maker)Firstpublished2007Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,withoutthepriorpermissioninwritingofOxfordUniversityPress,orasexpresslypermittedbylaw,orundertermsagreedwiththeappropr
7、iatereprographicsrightsorganization.EnquiriesconcerningreproductionoutsidethescopeoftheaboveshouldbesenttotheRightsDepartment,OxfordUniversityPress,attheaddressaboveYoumustnotcirculatethisbookinanyotherbindingorcoverandyoumustimposethesameconditiononanyacquirerBritishL
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