甲状腺功能减退与子痫前期相关性的研究

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1、授予单位代码10089学号或申请号20123101蚵妗(£钭大5HebeiMedicalUniversity硕士学位论文专业学位甲状腺功能减退与子痫前期相关性的研究研究生：成明阳导师：辛虹教授专业：妇产科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任

2、。“101^年K月h日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：成郎导师签章：^ir年3月I曰目录中文摘要·············································································1英文摘要····································································

3、·········4英文缩写·············································································8研究论文甲状腺功能减退与子痫前期相关性的研究前言·············································································10材料与方法····································································10结果····························

4、·················································14附表·············································································17讨论·············································································21结论·············································································25参考文献··

5、·····································································25综述子痫前期与甲状腺功能异常············································29致谢···················································································40个人简历·············································································4

6、1中文摘要甲状腺功能减退与子痫前期相关性的研究摘要目的：探讨子痫前期（pre-eclampsia，PE）患者甲状腺功能减退的状况，并分析其与病情严重程度的相关性及其与母儿结局的关系。方法:回顾性分析2012年1月至2015年2月在河北医科大学第二医院产科门诊产检并住院分娩的孕妇共499例，其中PE患者349例，同时选取年龄、孕产次相似的孕晚期正常孕妇150例为对照组。排除孕前有高血压病、糖尿病、心脏病、肝肾功能不全病史；孕前有甲状腺功能亢进（以下简称甲亢）、甲状腺功能减退（以下简称甲减）、亚临床甲状腺功能减退（以下简称亚临床甲减）、多囊卵巢综合征、垂体和肾上腺等内分泌疾病史；孕前有甲状腺手术史

7、；本次妊娠患有妊娠期高血压、子痫、慢性高血压并发PE、妊娠合并慢性高血压；双胎或多胎妊娠；高龄初产。PE诊断标准依据谢幸、荀文丽主编的第八版《妇产科学》命名及分类，PE患者349例分3组：早发型重度子痫前期（severepreeclampsia，SPE）182例，晚发型SPE106例，晚发型轻度子痫前期（mildpreeclampsia，MPE）61例。妊娠期甲状腺功能诊断标准依据中华医学会内分泌