甲型流感病毒重要亚型的进化研究

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1、分类号•密级々>UDC保密期限博士学位论文题目甲型流感病毒重要亚型的进化研究ResearchontheevolutionofmajorsubtypesininfluenzaAvirus作者姓名MM指导教师梁龙研究员岳俊杰副研究员培养单位军事医学科学院生物工程研究所专业名称生物信息学论文提交日期2015年06月10日学位授予单位中国人民解放军军事医学科学院答辩委员会主席杨瑞馥研究员中国人民解放军军事医学科学院制军事医学科学院研究生学位论文独创性声明秉承军事医学科学院严谨的学风和科研作风，本人声明所呈交的学位论文

2、是本人在导师指导下独立进行的研究工作和取得的研究成果，除了文中特别加以标注和致谢之处外，论文中不包含其他人已经发表或撰写过的研究成果，也不句,含为莸得军事医学科学院或其它教育机构的学位或证书而使用过的材料。与我一同工作的同志对本研究所做的任何贡献均巳在论文中作了明确的说明并表示了谢意。论文作者签字：达签字日期：年广月日军事医学科学院保护知识产权声明本学位论文作者完全了解军事医学科学院对研究生在学其间撰写的论文知识产权保护的相关规定。本人撰写的论文是在导师具体指导下，并得到桕关研究经费支持下完成，其数据和研究成

3、果归属于导师和作者本人，知识产权单位属军事医学科学院。本人保证毕业后，以本论文数据和资料发表论文或使用论文工作成果时署名第一单位仍然为圣星事医学科学院有权倮留学位论文及其电子版,通过网站公布论文的全部或部分内容，可以采用影印、缩印或其他复制手段保存论文、汇编以供查阅和借阅。(涉密和延期公开学位论文在解密后适用本声明）论文作者签字：Pi^签字日期：20(S-年（月b日指导教师签字：签字日期••2.""5年4月曰分类号密级UDC保密期限博士学位论文题目甲型流感病毒重要亚型的进化研究Researchontheevo

4、lutionofmajorsubtypesininfluenzaAvirus作者姓名靳远指导教师梁龙研究员岳俊杰副研究员培养单位军事医学科学院生物工程研究所专业名称生物信息学论文提交日期2015年06月10日学位授予单位中国人民解放军军事医学科学院答辩委员会主席杨瑞馥研究员中国人民解放军军事医学科学院制目录目录目录···································································································

5、·····I英文缩略词表····························································································V摘要·····································································································VIIAbstract······································

6、·····························································XI第一章绪论·······························································································11.1甲型流感病毒概述··················································································

7、11.2甲型流感病毒宿主限制性及其分子机制·····················································41.3甲型流感病毒进化动力与相关研究···························································51.3.1抗原漂变····························································································51.

8、3.2抗原转变与重配···················································································61.4论文的主要工作和创新点········································································81.4.1本文相关研究方法与拟解决的科学