Principles of computational modelling in neuroscience (2011) - Sterratt .pdf

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1、ThispageintentionallyleftblankPrinciplesofComputationalModellinginNeuroscienceThenervoussystemismadeupofalargenumberofelementsthatinteractinacomplexfashion.Tounderstandhowsuchacomplexsystemfunctionsrequirestheconstructionandanalysisofcomputationalmodelsatmanydifferentlevels.Thi

2、sbookprovidesastep-by-stepaccountofhowtomodeltheneuronandneuralcircuitrytounderstandthenervoussystematmanylevels,fromionchan-nelstonetworks.Startingwithasimplemodeloftheneuronasanelectricalcircuit,graduallymoredetailsareaddedtoincludetheeffectsofneuronalmor-phology,synapses,ion

3、channelsandintracellularsignalling.Theprincipleofabstractionisexplainedthroughchaptersonsimplifyingmodels,andhowsim-plifiedmodelscanbeusedinnetworks.Thisthemeiscontinuedinafinalchapteronmodellingthedevelopmentofthenervoussystem.Requiringanelementarybackgroundinneuroscienceandsome

4、highschoolmathematics,thistextbookprovidesanidealbasisforacourseoncomputationalneuroscience.Anassociatedwebsite,providingsamplecodesandup-to-datelinkstoexter-nalresources,canbefoundatwww.compneuroprinciples.org.DavidSterrattisaResearchFellowintheSchoolofInformaticsattheUniversi

5、tyofEdinburgh.Hiscomputationalneuroscienceresearchinterestsincludemodelsoflearningandforgetting,andtheformationofconnectionswithinthedevelop-ingnervoussystem.BruceGrahamisaReaderinComputingScienceintheSchoolofNaturalSci-encesattheUniversityofStirling.Focusingoncomputationalneur

6、oscience,hisresearchcoversnervoussystemmodellingatmanylevels.AndrewGilliesworksatPsymetrixLimited,Edinburgh.Hehasbeenactivelyinvolvedincomputationalneuroscienceresearch.DavidWillshawisProfessorofComputationalNeurobiologyintheSchoolofInformaticsattheUniversityofEdinburgh.Hisrese

7、archfocusesontheappli-cationofmethodsofcomputationalneurobiologytoanunderstandingofthedevelopmentandfunctioningofthenervoussystem.PrinciplesofComputationalModellinginNeuroscienceDavidSterrattUniversityofEdinburghBruceGrahamUniversityofStirlingAndrewGilliesPsymetrixLimitedDavidW

8、illshawUniversityofEdinburghCAMBRIDGEUNIVERSITYPRESSCa