ykl-40在变应性鼻炎患者中血清的表达及与血清il-4、ifn-γ相关性分析

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1、分类号：R765.2密码：一般UDC：616.2编号：2010212336硕士学位论文YKL-40在变应性鼻炎患者中血清的表达及与血清IL-4、IFN-γ相关性分析研究生：刘飞导师：高春生教授申请学位级别：医学硕士年级：二零一零级学科专业：耳鼻咽喉科学研究方向：鼻科学与变态反应论文提交日期：2013年5月论文答辩日期：2013年5月学位类型：专业型学位授予单位：广州医科大学答辩委员会主席：陈向东教授评阅人：陈向东、杜冀晖教授2013年5月硕士学位论文YKL-40在变应性鼻炎患者中血清的表达及与血清IL-4、IFN-γ相关性分析ExpressionofserumYKL-40i

2、nanaphylacticrhinitispatientsandassociationofserumYKL-40withserumIL-4andIFN-γ研究生姓名：刘飞年级：二〇一〇级学科专业：耳鼻咽喉科学导师姓名：高春生导师单位：深圳市第六人民医院广州医科大学·广州二〇一三年五月目录中文摘要·····························································································1英文摘要············································

3、·················································5主要符号表··························································································6前言·····························································································7资料与方法···········································

4、··············································10结果····························································································16讨论···························································································20结论·················································

5、···········································28参考文献····························································································29综述····························································································32附录·················································

6、···········································37攻读硕士学位期间研究成果····································································47致谢····························································································48原创性及知识产权声明·························································

7、·················49YKL-40在变应性鼻炎患者血清中的表达及与IL-4、IFN-γ相关性分析学科专业：耳鼻咽喉科学学位申请人：刘飞指导老师：高春生教授中文摘要背景：变应性鼻炎是耳鼻咽喉科的常见病，其患病率高，对患者的生活质量影响广泛。目前变应性鼻炎的发病机制尚未完全明确，现有研究表明变应性鼻炎是体外环境因素作用于易感个体导致的异常免疫反应，表现为Th1和Th2细胞间免疫失衡而引起的以鼻腔黏膜Th2免疫反应为主的变应性炎症反应。YKL-40是一种哺乳动物糖蛋白，在一系列以炎症、异常细胞增殖、细胞重