2010 Medicines in development for Diabetes.pdf

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1、201R0eportMEDICINESINDEVELOPMENTFORDiabetesPRESENTEDBYAMERICA’SPHARMACEUTICALRESEARCHCOMPANIESBiopharmaceuticalCompaniesDevelopingaRecord235MedicinestoTreatDiabetesandRelatedConditionsiabetesisincreasingatanalarmingrateinMEDICINESINDEVELOPMENTFORDIABETES*America.Eachday,approximately4,110pe

2、opleDarediagnosedwithdiabetes.TohelpfightthisType1Diabetes24potentiallydevastatingdisease,America’spharmaceuitcalresearchandbiotechnologycompaniesareworkingonType2Diabetes144235newmedicinestotreatdiabetesandrelatedconditions.AllofthemedicinesinthisreportareeitherinclinicalUnspecified/OtherD

3、iabetes23trialsorawaitingapprovalbytheU.S.FoodandDrugAdministration.Diabetes-Related59ConditionsAccordingtotheAmericanDiabetesAssociation(ADA),diabetesaffectsmorethan20millionAmericans—about*Somemedicinesarelistedinmorethanonecategory.8percentoftheU.S.population—andathirdareunawaretheyhavet

4、hedisease.Unfortunately,therateofnewdevelopingtype2diabetes,medicineshavebeencriticalcasesandthedeathrateduetodiabeteshasbeenrising.toimprovingandlengtheningthelivesofthosesufferingTherateofnewcasesrosebymorethan90percentamongfromit.adultsoverthelast10years,accordingtoa2008studyThenewmedici

5、nesindevelopmentinclude:bytheU.S.CentersforDiseaseControlandPrevention.Since1987,thedeathrateduetodiabeteshasincreased•Aonce-weeklymedicinethatisananalogofanaturalby45percent,evenasdeathratesduetoheartdisease,humanhormonethatplaysasignificantroleinbloodstroke,andcancerhavedeclined.sugarregu

6、lation.Withthestakesthishigh,America’spharmaceutical•Adrugthataddressestheunderlyingcauseoftype2companiesarecommittedtodevelopingnewmedicinesdiabetesbymodulatinggenesresponsibleforinsulintotreatdiabetes.sensitization.AccordingtotheADA,mostAmericanswithdiabetes•Aonce-dailymedicinethatselecti

7、velyinhibitsaproteinhavetype2,inwhichrelativeinsulindeficiencycombinesassociatedwithglucosemetabolism,butnototherwiththebodyfailingtoproperlyuseinsulin.Betweenrelatedproteinsassociatedwithotherbiologicactivity.5percentand10percentofAmericanswithdiabetesh