Rhodium-Catalyzed C–H Bond Arylation of Arenes.pdf

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1、TopCurrChem(2010)292:231–280DOI10.1007/128_2009_12©Springer-VerlagBerlinHeidelberg2009Publishedonline:3October2009Rhodium-CatalyzedC–HBondArylationofArenesJeanBouffardandKenichiroItamiAbstractAreviewispresentedofsyntheticmethodsforthepreparationofbiarylsby

2、therhodium-catalyzedC–Hbondarylationofareneswitharylhalides(C–H/C–Xcouplings),arylmetalreagents(C–H/C–Mcouplings)andarenes(C–H/C–Hcouplings),withanemphasisonpostulatedmechanismsandtheirimplicationsonreactivity,selectivityandsubstratescope.KeywordsBiaryls•C

3、atalysis•C–Hactivation•Cross-coupling•RhodiumContents1Introduction.........................................................................................................................2321.1Biaryls,Cross-CouplingandthePromiseofC–HFunctionalizationMethod

4、s..........2321.2Rh-MediatedCleavageofAreneC–HBonds.............................................................2342C–H/C–XAreneArylation(Rh-CatalyzedCondensationMethods)..................................2352.1Rh-CatalyzedC–H/C–XArylationofArenesThroughEle

5、ctrophilicMetalation......2352.2Rhodium-CatalyzedC–H/C–XArylationofArenesThroughN-HeterocyclicCarbeneFormation......................................................................................................2422.3Rh-CatalyzedC–H/C–XArylationofArenesTh

6、roughDirectedMetalation.............2512.4Rh-CatalyzedC–H/C–XArylationofArenesThroughOtherorUnknownMechanisms............................................................................................2573C–H/C–MAreneArylation(Rh-CatalyzedOxidativeCoupling

7、Methods).......................2593.1Rh-CatalyzedC–H/C–MArylationofArenesThroughDirectedMetalation............2594C–H/C–HAreneArylation(Rh-CatalyzedOxidativeCouplingMethods)........................2675ConclusionsandOutlook..................................

8、..................................................................271References.................................................................................................................................