Ageing Res Rev_2011;10(1) [Cell Motility and Ageing] .pdf

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1、AgeingResearchReviews10(2011)1–15ContentslistsavailableatScienceDirectAgeingResearchReviewsjournalhomepage:www.elsevier.com/locate/arrReviewEffectofagingoncellularmechanotransductiona,b,db,ca,b,da,ea,b,c,d,*MiaozongWu,JacquelineFannin,KevinM.Rice,BinWang,EricR.BloughaCellDifferenti

2、ationandDevelopmentCenter,MarshallUniversity,Huntington,WV,UnitedStatesbDepartmentofBiologicalSciences,MarshallUniversity,Huntington,WV,UnitedStatescDepartmentofPharmacology,PhysiologyandToxicology,MarshallUniversity,JoanC.EdwardsSchoolofMedicine,Huntington,WV,UnitedStatesdDepartme

3、ntofExerciseScience,SportandRecreation,CollegeofEducationandHumanServices,MarshallUniversity,Huntington,WV,UnitedStateseDepartmentofChemistry,MarshallUniversity,Huntington,WV,UnitedStatesARTICLEINFOABSTRACTArticlehistory:Agingisbecomingacriticalheathcareissueandaburgeoningeconomicb

4、urdenonsociety.Received14July2009Mechanotransductionistheabilityofthecelltosense,process,andrespondtomechanicalstimuliandisReceivedinrevisedform11November2009animportantregulatorofphysiologicfunctionthathasbeenfoundtoplayaroleinregulatinggeneAccepted16November2009expression,protein

5、synthesis,celldifferentiation,tissuegrowth,andmostrecently,thepathophysiologyofdisease.Herewewillreviewsomeoftherecentfindingsofthisfieldandattempt,wherepossible,toKeywords:presentchangesinmechanotransductionthatareassociatedwiththeagingprocessinseveralselectedAgingphysiologicalsyste

6、ms,includingmusculoskeletal,cardiovascular,neuronal,respiratorysystemsandMechanotransductionskin.MusculoskeletalPublishedbyElsevierIrelandLtd.CardiovascularNeuronalRespiratorysystemSkin1.Introductionologyofdisease(Ingber,2003a).Recentdatastronglysupportsthisnotionasitisbecomingreco

7、gnizedthatmanyaspectsofTheagedpopulationnowcomprisesthefastestgrowingsarcopenia,cardiovascularandrespiratorydiseasemayberelatedsegmentofpeoplelivingintheUnitedStates.Livinglongeristoalterationincellularmechanotransduction(Bloughandassociatedwithhighermorbidity.Indeed,healthcarespen

8、dingperLinderman,2000;Rice