cell signaling in viral and oncogenic pathogenesis and its implications in disease diagnosis and prognosis

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1、142中山大学学报(医学科学版)第31卷thesecasestheetiologicalsignificanceofthe1Intr0ducti0nass0ciatedvirusesremainstobeestablished[引．Inthiscontext，widelyknownexamplesofetiologicalBothviraldiseasesandcanceraccountforavirus—cancerassociationsincludecorrelationsbetweenlargeproportionofserioushealthproblems．

2、HumanEpstein．Barrvirus(EBV)andlymphomasaswellvirusescauseacuteorchronicinfectionsleadingtoasnasopharyngealcarcinoma，acancertypewithitsdiseasespresentedassubclinicalormildthroughhighestgeographicprevalenceinsouthChinasevereorlethalconditions．Thisnotionisbecomingregions，betweenhepatitisB(H

3、BV)andCvirusesmoreandmoreprominentinrecentyearsasemerging(HCV)andprimaryhepatocellularcarcinoma(HCC)，aswellasre．emergingviruses，includingSARSbetweenHPVandcervicalcancer，betweenhumancoronavirusandpandemicorhighlypathogenicTlymphotropicviruses(HTLV)andadultT—cellinfluenzaviruses，frequently

4、hitandcirculateinleukemiaandhairy．cellleukemia，andbetweenhumanhumanpopu1ations，whileothercommonandclassicallyherpesvirus8(HHV-8)andKaposisarcoma．health—threateningviruses，suchashepatitisviruses，Moreover，othervirusesarealsosuspectedtobehumanimmunodeficiencvvirus(HIV)andhumanindirectlyordi

5、rectlyassociatedwithhumancancers，papillomavirus(HPV)，continuetocausepathogenicsochashumanendogenousretroviruses(HERV)，infections．Ontheotherhand，cancerasaclassofmousemammarytumorvirus(MMTV)andrecentlydeadlydiseaseswithcomplicatedpathogenesisandareportedxenotropicmurineretrovirus(XMRV)I5]．

6、lethalclinicalendpointremainsgenerallyunsolved，Atthemolecularandthecellularlevels，studiesondespitethetremendousscientificandtechnologicalviraloncogenecityhavetremendouslyimprovedouradvancementsmadeinthepastseveraldecades，generalunderstandingofcarcinogenesis，forinstances，duetowhichcertain

7、cancertypesarebecomingthediscoveriesofoncogenesandtumorsuppressorsomewhatmanageable．Alargenumberoffactors，genes．Itisofgreatinteresttonotethatsomecellularenvironmentalorgenetic，havebeenexperimentally，pathwaysaresharedbythedevel0pment／progressionepidemiologicallyorclinicall