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时间:2019-03-06
《肾茶化学成分的研究》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、天然产物研究与开发NatProdResDev2009,21:608-611,592文章编号:1001-6880(2009)04-0608-05肾茶化学成分的研究谭俊杰,谭昌匣,陈伊蕾,蒋山好,朱大元中国科学院上海生命科学研究院上海药物研究所新药研究国家重点实验室,上海201203摘要:从肾茶中分离得到11个已知化合物,通过NMR及MS数据分析,分别鉴定为:5一羟基-6,7,4'--'Ep氧基黄酮(1),5.羟基一6,7,3,4'-四甲氧基黄烷N(z),orthosipholF(3),siphonolB(4),白桦酯酸(5),2d一羟基齐墩果酸(6),2d,3ct
2、-二羟基.12.烯-28一齐墩果酸(7),委陵菜酸(8),蔷薇酸(9),熊果酸(10)和胡萝卜甙(11)。其中,化合物2—9为首次从该植物中分离得到。关键词:肾茶;唇形科;黄酮;二萜;三萜中图分类号:R284.1;Q946.91文献标识码:AChemicalConstituentsofClerodendranthusspicatusTANJun-jie,TANChang—heng,CHENYi—lei,JIANGShan—hao,ZHUDa—yuanStateKeyLaboratoryofDrugResearch,ShanghaiInstituteofMater
3、iaMedwa,ShanghaiInstitutes-厂0rBio~gwalSciences,ChineseAcademyofSciences,Shanghai201203,ChinaAbstract:ElevencompoundswereisolatedfromtheCHC1fractionofthe95%ethanolextractofClerodendranthusspica—tus(Thunb.)C.Y.Wu,whichwereidentifiedtobe5-hydroxy-6,7,4'-trimethoxyflavone(1),5-hydroxy-6,
4、7,3,4'-tetra—methoxyflavanone(2),orthosipholF(3),siphonolB(4),betulinicacid(5),maslinicacid(6),2ct,3-dihydroxyolean·12一en-28一oicacid(7),tormenticacid(8),euscaphicacid(9),ursolieacid(10)anddaucosterol(11)onthebasisofspectralanalysis.Amongthem,compounds2-9wereobtainedfromthetitleplantf
5、orthefirsttime.Keywords:Clerodendranthusspicatus;Labiatae;flavone;diterpene;triterpenemaslinicacid(6),3-epimaslinicacid(7),tormenticIntroductionacid(8),euscaphicacid(9)andursolieacid(10),asClerodendranthusspicatus(Thunb.)C.Y.Wu,knownwellasdaucosterol(11).Amongthem,2-9werefirstlyas“re
6、naltea”or“maoxucao”.isapopularmedicinalobtainedfromthetitleplant.Here,wedescribetheiso—herbforthetreatmentofchronicnephritis,urinarylithi—lationandstructureelucidationoftheabovecom.asis,hepatitis,jaundiceandbiliarylithiasisinSouth—pounds.eastAsia[¨.Previousstudiesonthiswholeplantresu
7、l—Experimentaltedintheisolationofflavonoids,polyphenolicacidsandditerpenes[24]InthecourseofDhytochemicalin.General.vestigationonthewholeplants,weobtainedelevenOpticalrotationsweremeasuredusingaPerkin—Elmerknowncompounds,comprisingtwoflavonoids:5一hy—341polarimeter.UVspectrumwasconduct
8、edwithAgi-le
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