福州地区大气可吸入颗粒物致胎儿心血管畸形流行病学研究

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1、分类号：714.35学校代码：10392专业代码：100211学号：2101003367福建医科大学硕士学位论文福州地区大气可吸入颗粒物致胎儿心血管畸形流行病学研究EpidemiologyresearchonrelationshipbetweeninhalableairborneparticulatematterandfetalcardiovascularmalformationsinFuzhouarea学位类型：医学硕士所在学院：福总临床医学院研究生：施淼学科、专业：妇产科学导师：洪新如教授研究起止日期：2011年7月至2013年3月答辩日期：2013年5月21日二0

2、一三年五月12目录缩略词表··················································································1论文摘要中文摘要·········································································2英文摘要·········································································4研究内容前言··························

3、···············································7资料与方法·······································································10结果·······································································15讨论·······································································22结论··········

4、·····························································27参考文献················································································28致谢················································································33综述·····················································

5、···························34附录················································································423英文缩略名词对照表Abbreviations英文缩写英文全称中文全称CIConfidenceinterval置信区间COCarbonmonoxide一氧化碳EPAEnvironmentalProtectionAgency环保署ICD-10InternationalClassificationofDiseases-10国际疾病分类第10版NO2Ni

6、trogendioxide二氧化氮O3Ozone臭氧OROddratio相对危险度PMParticulatematter颗粒物PM2.5Fineparticles细颗粒物PM10Inhalableparticulatematter可吸入颗粒物SO2Sulfurdioxide二氧化硫UFPsUltrafineparticles超细颗粒物1福州地区大气可吸入颗粒物致胎儿心血管畸形流行病学研究中文摘要目的探讨妊娠早期大气可吸入颗粒物（inhalableparticulatematter，PM10）暴露与胎儿心血管畸形的关系。方法采用病例对照研究的方法，收集2007年5月14日

7、至2012年4月30日期间南京军区福州总医院和福建省妇幼保健院胎儿畸形孕妇资料，针对胎儿心血管畸形类型，在同时期（估计受孕日期相差＜30d）的病例资料中，按照1∶1的比例随机抽取正常活产孕妇作为相应对照组。大气污染物PM10数据由福建省环境监测中心站提供，为2007年1月1日至2012年4月30日福州市4个监测点（国控）PM10的日均浓度值。病例-对照组每名孕妇个体PM10暴露值是根据每名孕妇所提供的详细家庭住址计算其所处的经纬度而确定的个体日均PM10暴露浓度。采用两配对样本t检验比较各畸形组与对照组妊娠第1、2、3月和1～3个月PM1