鸟分枝杆菌复合群对16种抗感染药物药敏试验的分析

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1、万方数据生垡结擅塑壁噬苤壶垫!Q笙!旦箍翌鲞筮!魍gh迪!垒垒墼壁竺e堡堕!：!!型垫!Q：!吐：32：盟!：!鸟分枝杆菌复合群对16种抗感染药物药敏试验的分析段鸿飞土井教生李琦马屿陈效友傅瑜【摘要】目的通过比较3种新型喹诺酮类药物(西他沙星、加替沙星和莫西沙星)与其他13种抗感染药物对鸟分枝杆茵复合群(MAC)分离株的体外活性，初步探讨喹诺酮类药物用于治疗MAC疾病的可能性。方法琼脂梯度稀释法测定J：述16种抗感染药物对MAC分离株的最低抑菌浓度(MIC)，比较其能抑制90％菌株生长的MIC(MIC蚰)。结果与胞内分枝杆菌相

2、比，鸟分枝杆菌菌株的MIC范围分布更广，且MIC∞多高于胞内分枝杆菌。4种大环内酯类药物中，克托霉素对鸟分枝杆菌和胞内分枝杆菌的MIC帅最低，分别为32和16ms／L；4种利福霉素类化合物中利福手证齐对鸟分枝杆菌和胞内分枝杆菌的MIC帅最低，分别为0．5和0．25ms／L；5种喹诺酮类药物中西他沙星对鸟分枝杆菌和胞内分枝杆菌的MIC∞最低，均为4mg／L，加替沙星和莫西沙晕均为8me／L。2株克拉霉素敏感株(MIC=0．5mg／L)对其他抗感染药物均接近或达到MIC范围的下限，3株克托霉素不敏感株(MIC=64ms／L)对除喹

3、诺酮类以外的抗感染药物均接近MIC范围的上限。结论利福拉齐、两他沙星、加替沙星和莫西沙星对MAC分离株具有较强的体外活性。【关键词】分枝杆菌，鸟复合；微生物敏感性试验SusceptibilitytestoftheMycobacteriumaviumcomplextosixteenanti-infectiveagentsD删ⅣHong-fei’．DOINo渤．UQt．MAYu，CHENXiao-you，FUYm卑DepartmentofGeneralInternalMedicine．Beiji唱孔瓜rculosis&‰racic

4、TumorResearchInstitute。Be讲ng101149，ChinaCorrespondingamhor：FUYu，DepartmentofGeneralInternal既丽增Tuberculosis＆‰racicTumorResearchInstitute，Beijing101149，China，Email：知伊@tbl23．org【Abst阳n】0bjectiveTocomparetheinvitroactivitiesof13anti-infectiveagentsand3newquinolones(sita

5、lloxaein，gatifloxacinandmox讥oxacin)againstMycobacteriumaviumcomplex(MAC)isolates，andthereforetoexplorethepossibilityofusingthesequinolonestotreatMACdiseases．MethodsTheminimalinhibitoryconcentration(MIC)oftheabove16anti．infectiveagents．includingsitafloxacin．gatifloxa

6、cinandmoxifloxacinagainstMACisolateswasdeterminedbyusingagardilutionmethods。andthentheMIC∞Softhedifierentanti．infectiveagentswerecompared．ResultsTheMICsof胍aviumisolatesshowedawiderrangeandwaglesssensitivetomostoftheanti．infectiveagents鼬comparedwith胍intraceUulareisol

7、ates．TheMICmsofclarithromycinagainstM．aviumand胍intracellulareisolateswere32ms／Land16me／L，respectively，whichWerethelowestamong4maerolidecompounds．rr}leMIC叼ofrifalazilwere0．5m∥Land0．25ms／L，respectively，whichweretheIowestamong4rifamycincompounds．TheMIC％ofsitafloxaeinag

8、ainstM．aviumandM．intraceUularelsolateswereboth4m∥L．whichwerethelowestamong5quinolones．Forgatifloxaciuandmoxifloxacin，theMIC吣againstM．avium