小半夏汤对水貂呕吐模型作用机制研究

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1、小半夏汤对水貂呕吐模型作用机制研究摘要目的本文对经方《金匮》小半夏汤按原方配伍对半夏、生姜各自的有效成分进行提取，制成质量稳定，方便携带的颗粒制剂，在新型水貂呕吐模型上研究小半夏汤(smallpinelliaedecoction，XBXT)&呕作用及机制。方法用顺铂(7．5mg．kg。1)、阿朴吗啡(1．6mg·kg"1)制备水貂呕吐模型。提取XBXT(半夏：生姜=1：1)有效成分制备成颗粒，给予水貂灌(翊XBXT(相当于给予4．0，1．0g'kg"1生药量)30rnin后，再腹腔注射(功顺铂或阿朴吗啡，研究XBXT对外周和中枢性两种呕吐模型的抑制作用及机制

2、。结果XBXT可抑制顺铂(72h内)引起的急性和延迟性呕吐，减少干呕和呕吐次数并延长呕吐潜伏期(尸

3、MechanismofSmallPinelliaeDecocnononMinkVomitModelAbstract0bjective：SmallPinelliaeDecoction(XBXT)isfromtheEasternHanZhangZhongjing’s”GoldenChamber”．XBXTconsistsofPinelliaTuberandGinger．WeextractedtheactiveingredientsfromXBXTtomakethegranulesandusedcisplatinandapomorphinetopreparemin

4、kvomitingmodelbygavagetostudytheantiemeticeffectofXBXTanditsmechanism．Methods：TheactiveingredientswereextractedfromXBXT(pinelliatuber：ginger=l：1)tomakethegranules．Cisplatin(7．5mg·kg～，ip)andapomorphine(1．6mg·k91，ip)wereusedtoprepareminkvomitingmodel．After30minofXBXT(equivalentto4．0，

5、1．Og·k91crudedrug)ig．adminstration，minkswereadministeredofcisplatinormorphinetostudytheinhibitoryeffectandmechanismofXBXTonthetwomodelsofvomiting．Results：XBXTcouldinhibitacuteanddelayedvomitinginducedbycisplatin(within72h)intheminks，reducethenumberofretchingandvomiting(P

6、ngthelatencytovomit(P<0．01)，andinhibittheexpressionofNKlreceptorincentral(theareapostrema)andperipheral(ileumtissue)tissues(P

7、sion：XBXTCaninhibitvomitinginducedbycisplatinandapomorphine，anditsmechanismisrelatedtotheinhibitionofcentralandperipheralNKlreceptorexpression．Postgraduatestudent：RenXu-ying(Pharmacology)DirectedbyProfessor：YueWangKeywords：smallpinelliaedecoction(XBXT)；mink；vomiting；cisplatin；apomo

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