超声弹性成像联合血清标志物评估慢性乙肝肝纤维化的价值研究

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1、窗单臓輙合性乙肝畴直研究2018-03-2001:26:12中国现代医生2018年1期李颖黄岩花陈方红［摘要］戸的探讨超声弹性成像联合血清标志物在慢性乙肝肝纤维化评估屮的价值。方法选取我院2015年7月〜2017年5月于传染科收治的慢性乙肝患者87例，采用超声弹性成像联合血淸标志物对患者进行检查，选取同期來医院体检的69例健康者作为对照组，采用血清标志物对患者进行检查。比较两组血清标志物检查结果，并评估慢性乙肝患者肝纤维化的分期情况。结果观察组透明质酸(HA)、层粘连蛋片(LN)和IV熨胶原蛋白(IV-C)等血清学指标明显高于对照组，差异有统计学意义

2、(Pv0.05)；患者肝纤维化程度与超声检测病理得分间存在正向相关性，差界具有统计学意义(90.864,P<0.05)；联合检测与病理活检的结果对照，准确度为96.55%(84/87)。结论采用超声弹性成像联合血清标志物对慢性乙肝患者进行肝纤维化评估，效果十分显着；可有助于了解患者肝纤维化的发展进程，直观、准确地获知肝纤维化的严重程度，对患者治疗方案的选择和预后的指导有十分重要的价值。［关键词］超声弹性成像；血清标志物；慢性乙肝；肝纤维化；价值［中图分类号］R512.6［文献标识码］B［文章编号］1673-9701(2018)01-0123-04Ev

3、aluationofthevalueofchronichepatitisbliverfibrosisbyultrasonographyincombinationwithserummarkersLIYingHUANGYanhuaCHENFanghongDepartmentofUltrasound.CentralHospitalofLishuiCityinZhejiangProvince,Lishui323000,China［Abstract］ObjectiveToexplorethevalueofultrasoundelasticimaginginth

4、eevaluationofchronichepatitisbliverfibrosis.MethodsAtotalof87casesofchronichepatitisbpatientsadmittedbyourhospitalfromJuly2015toMay2017inthedepartmentofinfectiousdiseaseswereselected,andthepatientswereexaminedbyultrasonicelasticimagingcombinedwithserummarkers,therewere69healthy

5、patientswhowereselectedforthesameperiod,thepatientswereexaminedbyserummarkers.Theresultsofthetwogroupsofserummarkerswerecomparedandthestagingofhepaticfibrosisinchronichepatitisbpatientswasevaluated.ResultsObservationgroupofhyaluronicacid(HA),laminin(LN)andtypeIVcollagen(IV・C)se

6、rologicalindexessuchassignificantlyhigherthanthecontrolgroup(P<0.05),thedifferencewasstatisticallysignificant；Therewasapositivecorrelationbetweenthedegreeofhepaticfibrosisandthepathologicalscoreofultrasonography(r=0.864,P<0.05),andthediffereneewasstatisticallysignificant；Theres

7、ultsofthejointtestwere96.55%(84/87)comparedwiththeresultsofpathologicalbiopsy.ConclusionTheliverfibrosisassessmentofchronichepatitisbpatientswasevaluatedbyultrasonic-elasticimagingcombinedwithserummarkers.Canhelptounderstandthedevelopmentofliverfibrosisinpatientswithprocess,int

8、uitiveandaccuratelyknowtheseverityofliverfibrosis,onth