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1、AAPSPharmSciTech2007;8(1)Article3(http://www.aapspharmscitech.org).ComparisonofaLaboratoryandaProductionCoatingSprayGunWithRespecttoScale-upSubmitted:January5,2006;Accepted:July13,2006;Published:January19,200711RonnyMuellerandPeterKleinebudde1InstituteofPharmaceuticsandBioph
2、armaceutics,Heinrich-Heine-University,Universitaetsstr.1,40225Duesseldorf,GermanyABSTRACTTheinfluenceofformulationfactorssuchasdensity,sur-facetension,viscosity,andprocessfactorssuchassprayrate,Alaboratoryspraygunandaproductionspraygunwereatomizationairpressure,distancefroms
3、praygun,sprayinvestigatedinascale-upstudy.TwoSchlicksprayguns,shape,spraygundesign,andliquidnozzlediameterondrop-whichareequippedwithanewantibeardingcap,wereusedletsize,dropletvelocity,andspraydensitywasdescribedinthisstudy.Theinfluenceoftheatomizationairpressure,2byAultonan
4、dTwitchell.Thepolymerdispersionviscosityspraygun-totabletbeddistance,polymersolutionviscos-isoneofthemostimportantformulationvariables.Theef-ity,andsprayratewereanalyzedinastatisticaldesignoffectsofdifferentparameters(sprayrate,gun-to-tabletbedexperiments.The2spraygunswereco
5、mparedwithrespectdistance,atomizationairpressure,sprayshape,andspraytothespraywidthandheight,dropletsize,dropletvelocity,gundesign)onthefilmcoatqualitywereexaminedfordif-andspraydensity.Thedropletsize,velocity,andspraydensi-3ferentsprayguns.tyweremeasuredwithaPhaseDopplerPar
6、ticleAnalyzer.Asuccessfulscale-upoftheatomizationisaccomplishedifInadditiontotheatomizationprocess,acombinationofmanysimilardropletsizes,dropletvelocities,andspraydensitiesotherprocessandformulationvariablesisnecessaryfora4areachievedintheproductionscaleasinthelaboratorygood
7、coatingresult.Infilmcoating,manydifferentsprayscale.Thisstudygivesbasicinformationforthescale-upofgunsareused.Two-componentjetsarethemostcommonlythesettingsfromthelaboratorysprayguntotheproductionusedspraygunsinfilmcoating.spraygun.Bothspraygunsarehighlycomparablewithre-Thes
8、cale-upoffilmcoatingprocessesisanimportantissuespecttothedropletsizeandvelo
