2型糖尿病患者血清gh,igf—i浓度改变及相关因素的研究

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1、维普资讯http://www.cqvip.comj{j辞2000年第8巷第2·81·2型糖尿病患者血清GH、IGF—I浓度改变及相关因素的研究0r1J]，J／一一刘道平汪寅黄兆坚摘要目的通过放免测定方法了解2型DM患者GH／IGF—I轴的改变与1型DM患者有何不同。方法对l9倒1型DM和98倒2型DM患者的血清基础GH及IGF—I浓度进行测定将2型DM患者血清IGF—I浓度与其各项临床及生化指标进行多元相关回归分析。结果1型DM患者GH水平(2．53士051~g／L)明显高于对照组(136士027~g／L，P<0．0S)；IGFI水平(I915土14．1#g／L)则显著低于对照组(266

2、．3工177~g／L，P<001)。2型DM患者GH(0．60=0．1l#g／L)水平与对照组(0．74土007~g／L)无显著性差异(P>0．05)+IGF—I(126．1士3．2~g／L)水平较正常(1534土8．3~g／L)明显降低(P

3、hestudyonchangesofbasiclevelsofserumGHandIGF—Iinpatientswithtype2diabetesandtheirrelatedfactorsLiuDaoping，WangYinzhang，HuangZho&ian(DepartmentofEndocrinology，GeneralHospitalofP．L．A，Beijing100853)AbstractObjectiveTofindoutthedifferencesinthechangesofGH／IGF-Iaxisbetweentype2diabetesandtype1diabetes

4、usingradioimmunoassaymethod．MethodsBasicconcentrationsofserumGHandIGF—Iin19casesoftype1diabetesand98casesoftype2diabeteswereevaluated．Theclinicalandlaboratoryitemsoftype8diabeticpatientswerealsomeasuredforrelatedfactoranalysiswithserumIGFIconcentrationsResultsTheserumIevelsofIGF—I(191．5士141#g／L)i

5、ntype1diabeticpatientsweresignificantlylowerthanthoseofthecontrol(2663士177#g／L，P<0．O1)，whilethebasiclevelsofserumGH(2-53土051~g／L)weresignificantlyhigherascomparedwiththecontrol(1．36土0．27~g／L+P<0．05)．Intype2diabetes，theIGFIlevels(126．1±3．2#g／L)werealsosignificantlylowerthanthoseofthecontrol(153．4=

6、83#g／L，P0．05)ascomparedwithcontrol(0．74~0．07~g／'L)．Conc

7、lusionThechangesofbasiclevelsofserllmGHandIGFIinpatientswithtype8diabetesweredifferentfromthatoftype1diabetes．andthisabnormalGH，IGF—IaxismaybeduetopersistentelevatedIevelsofpatients’bloodglucose．KeywordsType2diabetesme