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1、舒肝解郁胶囊治疗广泛性焦虑障碍的临床研究乔云栓张士巧通讯作者崔卫东李丽高兴陈英光河北衡水市精神病医院河北衡水053800【摘要】目的：探讨舒肝解郁胶囊治疗广泛性焦虑障碍的疗效及安全性。方法：将60例广泛性焦虑障碍患者随机分为观察组和对照组各30例，观察组给予舒肝解郁胶囊治疗，对照组给予盐酸丁螺环酮治疗，6周为1疗程。于治疗前及治疗6周末采用汉密尔顿焦虑量表(HAMA)评定临床疗效，副反应量表(TESS)评定不良反应。结果：观察组显效率66.7%,有效率为87.0%；对照组:显效率60.0%,有效率为86.7%,两组患者疗
2、效比较无显著性差异(t=1.233,P>0.05)o且两组治疗后HAMA评分均较治疗前有显箸下降(P<0.01),治疗前后两组间HAMA评分无显著性差异(P>0.05),但两组治疗后副反应观察组小于对照组，TESS评分有显著性差异(PV0.05)。结论：舒肝解郁胶囊治疗广泛性焦虑障碍与盐酸丁螺环酮整体疗效相当，不良反应较少，值得临床推广使用。【关键词】舒肝解郁胶囊；盐酸丁螺环酮；不良反应；广泛性焦虑障碍【中图分类号1R277.7【文献标识码]B【文章编号11764-8999(2015)7-0495-01[Ab
3、stract】Objective:ToinvestigatetheefficacyandsafetyofShuganJieyucapsuleinthetreatmentofgeneralizedanxietydisorder.Methods:60patientswithgeneralizedanxietydisorderwererandomlydividedintoobservationgroupandcontrolgroupwith30casesineachgroup,theobservationgroupwasgiv
4、enShuganJieyucapsuletreatment,thecontrolgroupwasgivenbuspironehydrochloridetreatment,6weeksfor1courses.Onthe6weekendoftreatmentandtheHamiltonAnxietyScale(HAMA)beforetreatmentandassessmentofclinicalefficacy,sideeffectsscale(TESS)assessmentofadversereaction.Results
5、:intheobservationgroupwas66.7%,effectiveratewas87%;thecontrolgroup:theeffectiveratewas60%,effectiveratewas86.7%,therewasnosignificantdiffereneebetweentheefficacyofthetwogroups(t=1.233,P>O.O5).AndthetwogrouptheHAMAscoreaftertreatmentthanbeforetreatmentwassignif
6、icantlydecreased(P<0.01),HAMAscorebeforeandaftertreatmentbetweenthetwogroupshadnosign讦icantdifferenee(P>0.05),butthetwogroupsaftertreatment,observationofsideeffectsingroupthanthecontrolgroup,thescoresofTESSweresign讦icantdifferenee(P<0.05).Conclusion:Shug
7、anJieyucapsuleratherintreatmentofgeneralizedanxietydisorderandbuspironehydrochlorideoverallcurativeeffect,lessadversereaction,itisworthyofclinicaluse.【keyword]Theliverresolvedepressioncapsule;Buspironehydrochloride;Adversereactions;Generalizedanxietydisorder广泛性焦虑
8、障碍(GAD)是一种以焦虑情绪为主要表现的神经症，是临床常见的精神性疾病，常表现为无明显原因和固定内容的担心，伴有明显自主神经功能紊乱。发病机制不明。通常病程迁延、难以痊愈、并常反复发作[1]。随着人们社会生活压力的增大，广泛性焦虑障碍的发病率呈现上升趋势。近年来，治疗焦虑障碍的药物较多，但由于疗效及药物副反应等因素
