具有聚集誘導發光特性的納米功能材料的生物應用開發

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1、ITP/008/09NPDevelopmentofFunctionalNanomaterialswithAggregation‐InducedEmission(AIE)CharacteristicsforBiotechnologicalApplications具有聚集誘導發光特性的納米功能材料的生物應用開發BenZhongTangDepartmentofChemistryTheHongKongUniversityofScience&TechnologyTheFirstProgressReport(From01/09/2009to31/03/2010)1Outline1.Introd

2、uction2.Deliverablesandmilestonesachieved•Design&synthesisAIEmolecules¾Tetraphenylethyleneandsilolederivatives¾Silicananoparticles•UrinaryProteinDetectionAssayKitAIENanomaterialsforBiotechnologicalApplications2Fluorescent-BasedTechniquesandNanomaterials•Highsensitivity•Lowbackgroundnoises•Broa

3、ddynamicranges•Rapidity•Visualobservation•Highsurface‐to‐volumeratios•Surface‐modifiablequalityÎMultiplexprobesforsensoricapplicationsAIENanomaterialsforBiotechnologicalApplications3QuantumDotsInherentlycytotoxic!Comprisedheavymetalsandchalcogenselements(e.g.,ZnSe,CdS,PdTe)Thebiocompatibilityo

4、ffluorophoresareseriouslyconcerned.AIENanomaterialsforBiotechnologicalApplications4MostoftheorganicdyesarepronetoaggregatewhendispersedinaqueousmediaorboundtobiologicalmacromoleculesinlargequantitiesAggregationQuenchesLightEmission!Athornyprobleminthedevelopmentofefficientbioprobesorbiosensors

5、.Itwouldbefascinating,ifamoleculecanemitefficientlyuponaggregation.AIENanomaterialsforBiotechnologicalApplications56AIE-activemoleculesinventedinourlabHPSTPEAIENanomaterialsforBiotechnologicalApplications7Aggregation-inducedEmission•ExcellentemittersforthefabricationofOLED•Sensitiveprobesforth

6、edetectionofbiomoleculessuchasproteins&DNAAIENanomaterialsforBiotechnologicalApplications8ProjectObjectivesAIEdyesSilicaStainsForNanoaggregatesNanoparticlesGelElectrophoresisUrinaryProteinCellLabelingDetectionAIENanomaterialsforBiotechnologicalApplications9Stage1DesignandSynthesizeTetraphenyle

7、thyleneandSiloleDerivativesAIENanomaterialsforBiotechnologicalApplications10DesignofaTPE-basedAIEfluorogenforthiol-specificdetectionScheme1.Synthesesoffunctionalizedtetraphenylethenederivativesforthioldetection11ThiolDetection•Keycompon