重度子痫前期胎盘组织的体视学分析

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1、硕士学位论文growthrestriction，FGR)2例，新生儿窒息2例，无新生儿死亡；EOSP组剖宫产结束妊娠10例，FGR3例，新生儿窒息4例，新生儿死亡2例。对照组A剖宫产结束妊娠2例，自然分娩8例，无FGR，新生儿窒息及新生儿死亡；对照组B自然分娩lO例，FGR0例，新生儿窒息l例，新生儿死亡2例。五、结论1．重度子痫前期组观察到较多新生儿不良结局。2．光镜下LOSP组和EOSP组胎盘绒毛存在缺血、缺氧等病理学表现。3．电镜下LOSP组和EOSP组胎盘合体滋养细胞超微结构存在严重的损害。4．在重度子痫前期环境下，胎盘绒毛及合体滋养细胞超微结构的损伤，引起其生理功能的

2、改变，影响胎盘的运输和合成功能，可能参与胎儿的损伤。关键词子痫前期；早发型；胎盘；体视学V硕士学位论文AStereologicalStudyonHumanPlacentainSeverePreeclampsiaName：HuYu—qinSupervisor：HeYuan—liABSTRACTBackgroundpre—eclampsiaisadiseasewhichhappensduringpregnancy，andit’Smainclinicalmanifestationismultisystemfunctionaldisorderwithhypertension，Urine

3、proteinlevelimproveandedema．Itisamajorcauseofmaternalandfetalmorbidityandmortality．Accordingtothebloodpressureandproteinurialevels，pre-eclampsiaCanbesorttolightpre··eclampsiaandseverepre··eclampsia．Especially,severepre—eclampsiaisdangeroustomaterandfetus．AnAmericanscholarintroducedtheconcept

4、ofEarly-onsetSeverePreeclampsia(EOSP)inthe1980s．InourcountrythescholarYang-Zidefinedtheoneonstebefore32weeksEOSPandtheoneonsteafter32weeksarecalledLate—onsetseverePreeclampsia(LOSP)．Recentlly，themedicalworkersofobstetricspaidmoreattentionandshewtheirinterestingtotheEOSP．TheEOSPincidencerated

5、uringpregnancyis50／0-,7％，accountsfor20．锄ofseverepreeclampsism．Itisallimportantcauseofdeathofmaternalandfetal．HowtopreventandcureEOSPisaformidableproblemtothemedicalwokers．TherearemanydifferentviewsintheexistingresearchesofpathogenesisofEOSPandLOSP，Kadyrovobservedfull—thicknessofplacenta，foun

6、dthattheapoptosisinplacentaofpatient、ⅣitllEOSPobviouslyincreased．TheinvasionoftrophocyteWasrestricted，placentanidationwasshallowandspiralarterywasstenosal．SoCrispiconsideredthatEOSPWasaplacentaldesease，thentheLOSPWasamaternalone．Owingtotheclinicalsymptomsisrelievedaftertheplacentalexpulsion，

7、therelationsbetweenpathologicchangesoftheplacentaandsevereABSTRACTpreeclampsiacausesmoreandmoreattentionsofresearchers．Placentaisanorganwhichplaysanimportantroleinthepointofcirculationbetweenmothersandfetusofmetabolicchange，ofthehormonalandofimmuno