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1、AgeingResearchReviews10(2011)80–92ContentslistsavailableatScienceDirectAgeingResearchReviewsjournalhomepage:www.elsevier.com/locate/arrReviewThermalsensitivityintheelderly:AreviewSlavaGuergova∗,AndréDufourLaboratoired’Imagerie&NeurosciencesCognitives,F
2、RE3289UniversitédeStrasbourg–CNRS,21RueBecquerel,67087Strasbourg,FrancearticleinfoabstractArticlehistory:Agingisassociatedwithaprogressivedecreaseinthermalperception,asrevealedbyincreasedthermalReceived4January2010detectionthresholdsintheelderly.Thisre
3、ductioninthermosensitivityfollowsadistal–proximalpattern,Receivedinrevisedform19April2010withmorepronounceddecrementsobservedinthelimbsandintheperceptionofwarmthvs.cold.TheAccepted19April2010mainunderlyingcausesofthisseemtobeagingoftheskinandsubsequent
4、reductionsinthermoreceptordensityandsuperficialskinbloodflow.However,theresultsfromsomeanimalstudiesalsosuggestthatKeywords:changesintheperipheralnervesystem,particularlyfiberlossanddecreasedconductionvelocity,mayAgealsobeinvolved.Inthispaper,wereviewage-
5、relatedchangesinthethermalsensitivityofhumans,theirThermalsensitivityunderlyingmechanisms,andthestrengthsandlimitationsofsomeofthemethodologiesusedtoassessPerceptionTemperaturethesechanges.Peripheralnervesystem©2010ElsevierIrelandLtd.Allrightsreserved.
6、Quantitativesensorytesting1.Introductionesizedtoaccountforage-relateddecreasesinthermalsenses,theactualunderlyingmechanismsarestillobscure.Fromaneuroanatomicalstandpoint,thermalsensitivityreliesThepresentpaperreviewsstudiesonage-relatedchangesinoncompo
7、nentsoftheperipheralandthecentralnervoussystemshumanthermalsensitivity.Afterabriefpresentationoftheneu-suchas:thecutaneousfreenerveendingsandtheAandCpri-rophysiologicalandneuroanatomicalbasesofthethermalsensesmaryafferentfibers;thesecondarysomatosensor
8、yneuronsintheinhumans,quantitativesensoryexplorationsfromthepastfewdorsalhornofthespinalcord;thespinothalamictractus;thethala-decadesarepresentedanddiscussed.Finally,somepotentialmus;andtheprimaryandsecondarysomatosensorycortices.Ageund