灯盏花素联合治疗三七总皂苷对急性脑梗死大鼠模型tnos、inos的影响

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1、山两医科人学坝lj学位论义BreviscapineJointPNSonAcuteCerebralIschemiaModelsofEffectsofTNOSandiNOSobjectiveandsignificanceAbstractInrecentyears，inourcountry,cerebrovasculardiseasehavebeenriseingforthefristfataldisablingconditions．Annualdeathtollisabout150million，amongthemwithisc

2、hemiccerebrovasculardiseaseincidenceofallstokehighest70％，newmethodisneededforthetreatmentofischemiccerebrovasculardiseaseinclinicaltherapy．Cerebralinfarctionofischemiccerebrovasculardisease．refertothebrainbloodcirculationbarrier,causebloodsupplyorlackinterruption，m

3、akeitssupplyofbrainischemiaandhypoxiaanddeadsoftened．Inaddition，studiesshowthatNOandNOSinischemicbraininjuryhasanimportantrole．NOSasthekeyenzymesforthesyntheticofNO．LotsofresearchsshowthatTNOSexpressionincreaseincerebralischemia，catalyticsynthesisofexcessNO，thuspar

4、ticipateinischemicbraininjurypathophysiologicaIevents．ParticipateinnervedarmageisgenerallyconsideredthemainaxlebyguidetolivingiNOStypeNOScatalysisTheiNOSispathologicalstatusenzyme，expressionofiNOSinalargenumberwhencerebralischemiaparticipateindelayedneurotoxivity,m

5、ainlyactivatedglialcells，neutrophilsandmacrophagesproduce，ofbrainischemia，thelatteranimportantfactorinaggravatingbraindamage．Thus，inhibitionofTNOScontentandactivityofiNOSexpressionisconsideredoneofthecerebralinfarctiontreatmentway．Thereislonghistoryforthetraditiona

6、lChinesemedicinepanaxandbreviscapinethattreatmentthecerebralinfarction，curativeeffect，withthelong-termefficacystability，adversereaction，sideeffectsandsorare，Butthecurrentcombinationoftwomedicineshavenotbeenreportedathomeandabroad，thestudyonthemechanismisrare．Thisre

7、searchusePanaxcombineBreviscapineinterventioncerebralinfarctionintheratmodel，byobservingthePanaxcombineBreviscapineinratswithcerebralinfarctionTNOScontentandiNOSactivityandmechanismofchange，ExploretheimpactofcerebralinfarctiononserumTNOScontentandchargeoftheactivit

8、yofiNOS．Revealthemechanismoftreatmentofcerebralinfarction，thetheoreticalbasisforclinicalapplication．Methods50adultmaleSDratswererandomlydividedin