107例肺癌伴发抗利尿激素分泌异常综合征临床特征与治疗分析

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1、大连医科大学硕士学位论文较大。3．SIADH临床表现无特异性且需要与多种疾病和某些药物引起的低钠血症相鉴别，诊断主要依靠实验室检查，避免造成漏诊或延迟诊断。4．小细胞肺癌伴SIADH的临床症状可随肿瘤切除或化疗等病因的治疗而好转消失。5．相对低钠和相对高钠两组在治疗效果上是否有统计学差异有待进一步研究。关键词：肺癌抗利尿激素分泌异常综合征低钠血症2大连医科大学硕士学位论文ClinicalCharacteristicsandStrategiesontheTreatmentin107LungCance

2、rComplicatingSyndromeofInappropriateAntidiureticHormoneSecretionAbstractObjective：Discussandsummarizetheclinicalcharacteristicsandstrategiesonthetreatmentin107lungcancel"complicatingsyndromeofinappropriateantidiuretichormonesecretion(SlADH)，inordertop

3、rovidereferenceforclinicaldiagnosisofthepatientswithlungcancercomplicatingSIADH．Method：Aretrospectiveanalysisof107casesoflungCancercomplicatingSIADHinthefirstaffiliatedhospitalofDalianMedicalUniversityfromJanuary2009toDecember2012weregroupedaccordingt

4、othebloodsodiumlevel．PatientsenrolledmetthediagnosticcriteriaforSIADH(sodiumcontentoftheserumdeclining；sodiumcontentoftheurinaryincreasing；theosmolalityofplasmacolloiddeclining；urineosmolalitygreaterthanplasmaosmolality；primarydiseaseormedicationhisto

5、ry；plasmaAVPlevelsinappropriatelyincreasing；nosignificantedema,kidneyandadrenalfunctionnormally．excludingcirrhoticascites，chronicheartfailure，kidneydiseasewithhyponatremia)，thediagnosticcriteriaforlungCanCer(10ng—termsmokersabove40yearsofage，obviouscl

6、inicalmanifestations，theexaminationforchestX-rayandCT，andselectingbronchoscopy，sputumcytology，biopsyandothermethodstoobtainpathologicaldiagnosisoflungcanceraccordingtothepatient’Sconditionandtumorlocation)andsyndromeofinappropriatesecretionofantidiure

7、tichormoneforitsfirstclinicalmanifestationthattheprimarydiseaseislungCanCer．IthadtobeexcludedintheEnrolledpatientsthatwasassociatedwithotherseriousprimarylungdisease；youngerthan18yearsoldormorethan80yearsofage；pregnancyandbreast-feedingwomenonsetdisea

8、se；seriousprimarydiseaseforheart，cerebrovascular，liver,kidneyandbloodsystem；mentalillness；anddin’tcomplytheinclusioncriteriaorincompleteinformationpatients．UsingSPSS13．0processedthedatas．Normal3大连医科大学硕士学位论文distributionformeanstandarddeviation(