依达拉奉对洗涤式自体血回收中红细胞保护作用的研究

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1、广州医学院硕士学位论文依达拉奉对洗涤式自体血回收中红细胞保护作用的研究Studyofprotectiveeffectsofedaravoneonwashederythrocytesduringbloodsalvage专业名称：麻醉学学位申请人：程傲冰导师:许立新教授广州医学院·广州2012年5月目录中文摘要··········································································1英文摘要··································································

2、········3中英文对照·······································································6前言·············································································7材料与方法·····································································10结果·······················································

3、····················16讨论···········································································19结论···········································································26参考文献········································································27综述·······································

4、····································33攻读学位期间的研究成果···················································55致谢···········································································56学位论文原创性声明·························································57学位论文知识产权权属声明······································

5、··········57关于学位论文使用授权的说明·············································57广州医学院硕士学位论文依达拉奉对洗涤式自体血回收中红细胞保护作用的研究依达拉奉对洗涤式自体血回收中红细胞保护作用的研究专业：麻醉学硕士研究生：程傲冰导师：许立新教授广州医学院附属广州市第一人民医院麻醉科中文摘要目的探讨依达拉奉用于洗涤式自体血回收过程中对红细胞的保护作用及其机制方法将40例行择期脊柱手术的患者随机分为两组：依达拉奉组(E组)和对照组(C组)，每组20例。E组于手术开始前30min静脉滴注依达拉奉0.5mg/kg，并在自体血回收中的肝素

6、化生理盐水抗凝液、生理盐水洗涤液内加入依达拉奉(终浓度为3μg/ml)。C组给予等量生理盐水。分别测定术前外周静脉血、洗涤血红细胞+超氧化物歧化酶(SOD)活力、红细胞内G6PD含量、丙二醛(MDA)含量、Na，+2+2+k-ATP酶和Ca，Mg-ATP酶活性、红细胞渗透脆性、红细胞平均体积(MCV)、红细胞压积(HCT)、血红蛋白(Hb)和血浆中游离血红蛋白(FHb)等指标，同时,记录储血器内回吸血总量和回输血总量，按照公式[红细胞回收率(RR,%)=(V洗×HCT洗)/(V吸×HCT吸)×100%]计算自体血回收过程中红细胞的回收率。1广州医学院硕士学位论文依达拉奉对洗涤式自体血回收中红

7、细胞保护作用的研究结果1.两组病人的年龄、性别、手术时间、术中出血量、回输血量比较差异无统计学意义(P>0.05)。++2.两组患者回收前外周静脉血的SOD、G6PD、MDA、Na，k-ATP酶和2+2+Ca，Mg-ATP酶、红细胞渗透脆性、MCV、FHb、Hb、HCT比较差异无统计学意义(P>0.05)。3.两组患者洗涤血与外周静脉血比较，红细胞渗透脆性差异无统计学意义(P>0.05)；与外周静脉血比较，C