Cancer risk analysis and assessment of trihalomethanes in drinking water.pdf

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1、StochEnvironResRiskAssess(2006)21:1–13DOI10.1007/s00477-006-0039-4ORIGINALPAPERHan-KengLeeÆYir-YarnYehÆWei-MingChenCancerriskanalysisandassessmentoftrihalomethanesindrinkingwaterPublishedonline:22February2006ÓSpringer-Verlag2006AbstractThisstudyconductsriskassessmentforanar-Bellaretal.(1974)exhibi

2、tedthatdisinfectionby-prod-rayofhealtheffectsthatmayresultfromexposuretoucts(DBPs)wereproducedinthedisinfectionprocess.disinfectionby-products(DBPs).AnanalysisoftheNowadays,suchdisinfectionprocessismostadoptedinrelationshipbetweenexposureandhealth-relatedout-drinkingwatertreatmentcommonly(Houston19

3、13;comesisconducted.Thetrihalomethanes(THMs)spe-Yangetal.1998;Hsuetal.2001).cieshavebeenverifiedastheprincipalDBPsintheDisinfectionby-productsaredefinedashazardousdrinkingwaterdisinfectionprocess.ThedatausedinmaterialswithcarcinogenicriskbyTaiwanUSEPA.thisstudywascollectedfromtheTaiwanWaterCor-Anima

4、landepidemiologystudyevaluationshaveshownporation(TWC)from1998to2002.Statisticalanalysis,thatdevelopmentaltoxicityandadverseeffectsarethemultistageofBenchmarkmodel,MonteCarlosimula-mainpotentialriskstohumans.Theresultfromanimaltion(MCS)andsensitiveanalysiswereusedtoestimatestudiesdemonstratedeviden

5、ceofliver,kidney,intestinalthecancerriskanalysisandassessment.Thisstudyin-tumorgenesis,urinarybladder,rectumandcoloncancercludedthestatisticaldataanalysis,epidemiologyinves-(Morrisetal.1992;Doyleetal.1997;Cantoretal.1998)tigationandcancerriskassessmentofTHMsspeciesinandsomeassociatedeffectsofintrau

6、terinegrowthanddrinkingwaterinTaiwan.Itismoresignificanttoretardation(Krameretal.1992).Lowbirthweight,establishanassessmentprocedureforthedecisionsmallforgestationalage,centralnervoussystemdefects,makinginpolicyofdrinkingwatersafetypredomi-oralcleftdefectsandcardiacdefects(Boveetal.1995),nantly.ret

7、ardedfetalgrowth(Gallagheretal.1998)andspon-taneousabortion(Walleretal.1998)thatarecausedbyKeywordsDBPsÆMonteCarlosimulationÆdisinfectedwater.EpidemiologicstudieswereconductedMultistageofbenchmarkmodelÆSensitivea