左卡尼丁对维持性血液透析患者微炎症状态的影响

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1、左卡尼丁对维持性血液透析患者微炎症状态的影响向远湘李勇飞汪洋畅(广东省清远市清新区人民医院肾内科广东清远511800)【摘要】目的探讨左卡尼丁对维持性血液透析(MHD)患者微炎症状态的影响。方法选择透析龄超过6个月的MHD患者80例，随机分为治疗组和对照组。每次透析结束后，治疗组给予静脉注射左卡尼丁1克，疗程为3个月。治疗前和疗程结束后，分别测量患者血浆C反应蛋白(CRP)、白细胞介素1(IL-1)>白细胞介素6(IL・6)、肿瘤坏死因子(TNF-α)的含量。结果治疗组疗程完成后CRP、IL-1>IL・6、TNF-α均

2、较治疗前显著下降(P<0.05)；对照组IL・1疗程完成后较治疗前明显下降(P<0.05),CRP、IL・6、TNF-α疗程完成后虽较治疗前有所下降，但差异无显著性(P>0.05)；治疗后组间比较，CRP、IL・6、TNF-α差异有统计学意义，而IL-1治疗组虽较对照组下降，但差异无显著性(P>0.05)o结论左卡尼丁可明显改善患者的微炎症状态，提高透析患者的生活质量。【关键词】左卡尼丁血液透析微炎症状态【中图分类号】R459.6【文献标识码】A【文章编号】2095-1752(2013)14-0160-02Effect

3、sofL-carnifineonMicro-inflammnationConditionofMainfenanceHemodialysisXIANGYuanxiang,LIYongfei,WANGYangchang.DepartmentofNephrology,people'sHospitalofQingxinDistrictQingyuanCityinGuangdongProvince,Qingyuan511800,China【Abstract】ObjectiveDiscussingtheeffectofL-carnitin

4、eonmicro-inflammationconditionofmaintenancehemodialysis(MHD)patients.Method80MHDpatientswhohadHDformorethan6monthswereinvolved.Patientsweredividedintothetreatmentgroupandthecontrolgrouprandomly.ThetreatmentgroupweregivenintravenousinjectionofL-carnitinelgafterHDfor3monthes.

5、ThecontentofCRP,IL-1JL-6andTNF-αofpatientsweretestedbeforeandafterthetreatmentcourseseparately.ResultThecontentofCRP,IL-1JL-6andTNF-αofthetreatmentgroupdecreasedapparentlyafterthetreatmentcourse(P<0.05);thecontentofIL-1ofthecontrolgroupdecreasedapparentlycomp

6、aringtopriortreatment(P<0.05);CRP,IL-6andTNF-αreducedafterthetreatment,buttherewerenosign讦icantdifferencesbetweentpriorandafterthetreatment(P>O.O5).TherewerestatisticaldifferencesofCRRIL-6andTNF-αbetweenthetwogroupsafterthetreatment;whiletherewerenosign讦ic

7、antdifferencesofIL-1(P>O.O5)betweenthetwogroupalthoughtheparameterofthetreatmentgroupdecreased.ConclusionL-carnitinecouldimprovethemicro-inflammationconditionofthepatientapparently,andimprovethepatients’qualityoflife・【Keywords]L-carnitinehemodialysismicro-inflammat

8、ioncondition尿毒症患者普遍存在着以炎症细胞因子轻度升高为特征的微炎症状态[l]o而微炎症状态和尿毒症并发症有关。因此，微炎症状态的防治是降低尿毒症并发症