资源描述：
《基于反斯托克斯拉曼散射的非线性光学成像检测斑块new》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、DifferentiatingatheroscleroticplaqueburdeninarterialtissuesusingfemtosecondCARS-basedmultimodalnonlinearopticalimaging1122LeilaB.Mostaço-Guidolin,MichaelG.Sowa,AndrewRidsdale,AdrianF.Pegoraro,1111MichaelS.D.Smith,MarkD.Hewko,EliciaK.Kohlenberg,BernieSchattka,321
2、,MasashiShiomi,AlbertStolow,andAlexC.-T.Ko*1InstituteforBiodiagnostics,NationalResearchCouncilCanada,Winnipeg,R3B1Y6,Canada2SteacieInstituteforMolecularSciences,NationalResearchCouncilCanada,Ottawa,K1A0R6,Canada3InstituteofExperimentalAnimals,KobeUniversity,Scho
3、olofMedicine,Kobe650-0017,Japan*alex.ko@nrc-cnrc.gc.caAbstract:AfemtosecondCARS-basednonlinearopticalmicroscopewasusedtosimultaneouslyimageextracellularstructuralproteinsandlipid-richstructureswithinintactaortictissueobtainedfrommyocardialinfarction-proneWatanab
4、eheritablehyperlipidemicrabbits(WHHLMI).CleardifferencesintheNLOmicroscopicimageswereobservedbetweenhealthyarterialtissueandregionsdominatedbyatheroscleroticlesions.Inthecurrentex-vivostudy,wepresentasingleparameterbasedonintensitychangesderivedfrommulti-channel
5、NLOimagetoclassifyplaqueburdenwithinthevessel.Usingthisparameterwewereabletodifferentiatebetweenhealthyregionsofthevesselandregionswithplaque,aswellasdistinguishplaquesrelativetotheageoftheWHHLMIrabbit.©2010OpticalSocietyofAmericaOCIScodes:(170.3880)Medicalandbi
6、ologicalimaging;(170.4580)Opticaldiagnosticsformedicine;(180.4315)Nonlinearmicroscopy;(300.6230)Spectroscopy,coherentanti-StokesRamanscattering.Referencesandlinks1.P.Libby,“Atherosclerosis:diseasebiologyaffectingthecoronaryvasculature,”Am.J.Cardiol.98(12),S3–S9(
7、2006).2.G.K.Hansson,“Inflammation,atherosclerosis,andcoronaryarterydisease,”N.Engl.J.Med.352(16),1685–1695(2005).3.A.J.Lusis,“Atherosclerosis,”Nature407(6801),233–241(2000).4.B.K.Courtney,N.R.Munce,K.J.Anderson,A.S.Thind,G.Leung,P.E.Radau,F.S.Foster,I.A.Vitkin,R
8、.S.Schwartz,A.J.Dick,G.A.Wright,andB.H.Strauss,“Innovationsinimagingforchronictotalocclusions:aglimpseintothefutureofangiography’sblind-spot,”Eur.HeartJ.29(5),583–593
